Mice, myeloid cells, and dengue: a new model for unraveling vascular leakage mysteries
Takeshi Kurosu,
Yusuke Sakai,
Yasusi Ami
et al.
Abstract:IntroductionSevere dengue is thought to be caused by an excessive host immune response.MethodsTo study the pathogenesis of severe dengue, we developed a novel model using LysM Cre+Ifnarflox/flox mice carrying depleted Ifnar expression only in subsets of murine myeloid cells.ResultsAlthough dengue virus (DENV) clinical isolates were not virulent in LysM Cre+Ifnarflox/flox mice, mouse-adapted DV1-5P7Sp and DV3P12/08P4Bm, which were obtained by passaging the spleen or bone marrow of mice, demonstrated 100% lethal… Show more
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