Mice Lacking the p75NGFR Receptor Exhibit Abnormal Responses to Light

Golombék, Diego A.; Hurd, Mark W.; Lee, Kuo‐Fen; Ralph, Martin R.

doi:10.1076/brhm.27.3.409.12956

Cited by 12 publications

(4 citation statements)

References 34 publications

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“…Together, these data indicate that the expression of p75NTR in the SCN is not required for the transmission of entraining photic information to the SCN. Our findings contrast with those showing that mice with a targeted deletion of the p75NTR gene show an attenuation in light-induced phase shifts of circadian rhythms (18). However, the full extent of this mutation; its developmental impact; and, most importantly, its effect on normal photic entrainment have not yet been clarified.…”

Section: Discussioncontrasting

confidence: 99%

Effect of 192 IgG-Saporin on Circadian Activity Rhythms, Expression of P75 Neurotrophin Receptors, Calbindin-D28K, and Light-Induced Fos in the Suprachiasmatic Nucleus in Rats

Beaulé

Amir

2002

Experimental Neurology

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Section: Discussioncontrasting

confidence: 99%

Effect of 192 IgG-Saporin on Circadian Activity Rhythms, Expression of P75 Neurotrophin Receptors, Calbindin-D28K, and Light-Induced Fos in the Suprachiasmatic Nucleus in Rats

Beaulé

Amir

2002

Experimental Neurology

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“…and intra‐SCN injections of 192 IgG‐saporin led to an important reduction of light‐induced phase advances in the circadian rhythms of locomotor activity and core temperature. In accordance with this observation, mice with a targeted deletion of p75 NGF receptor have been found to be less sensitive to the phase shifting effect of light (Golombek et al ., 1996). Our data in rats provide support for the hypothesis that the anterior cholinergic projections modulate photic phase resetting of the SCN clock.…”

Section: Discussionmentioning

confidence: 62%

Modulation of photic resetting in rats by lesions of projections to the suprachiasmatic nuclei expressing p75 neurotrophin receptor

Erhardt

Galani

Jeltsch

et al. 2004

Eur J of Neuroscience

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The suprachiasmatic nuclei of the hypothalamus (SCN) are the site of the master circadian clock in mammals. The SCN clock is mainly entrained by the light-dark cycle. Light information is conveyed from the retina to the SCN through direct, retinohypothalamic fibres. The SCN also receive other projections, like cholinergic fibres from basal forebrain. To test whether cholinergic afferents are involved in photic resetting, lesions of cholinergic projections were performed in rats with intracerebroventricular (i.c.v.) injections or intra-SCN microinjections of 192 IgG-saporin. When injected in the SCN, this immunotoxin destroys the cholinergic projections and retinohypothalamic afferents that express p75 low-affinity nerve growth factor (p75(NGF)) receptors. The extent of lesions in the basal forebrain and SCN was assessed by acetylcholinesterase histochemistry, p75(NGF) receptor, choline acetyl-transferase, calbindin-D28K and VIP immunocytochemistry. The intra-SCN treatment reduced light-induced phase advances by 30%, and induced a complete loss of forebrain and retinal afferents expressing p75(NGF) receptors within the SCN and a decrease of forebrain cholinergic neurons, most likely those projecting to the SCN. The i.c.v. treatment reduced light-induced phase advances by 40%, increased phase delays and led to extensive damage of forebrain p75(NGF)-expressing neurons, while sparing half of the fibres expressing p75(NGF) receptors (retinal afferents?) in the SCN. Because the integrity of forebrain p75(NGF)-expressing neurons appears to be critical in mediating the effects on light-induced phase advances, we therefore suggest that anterior cholinergic projections expressing p75(NGF) receptors modulate the sensitivity of the SCN clock to the phase advancing effects of light.

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“…Ultradian rhythm ofNGF in healthy subjects with a "V" trend: higher at h. 9.00 (1) and h. 20.00(3) and lower at h. 13.00(2).…”

mentioning

confidence: 97%

Ultradian Variation of Nerve Growth Factor Plasma Levels in Healthy and Schizophrenic Subjects

Bersani

Iannitelli²,

Massoni³

et al. 2004

Int J Immunopathol Pharmacol

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Some studies in animal models showed that several neurotrophins may be implicated in the regulation of light-dependent suprachiasmatic pacemaker and in other functions implicated in long-term memory acquisition during sleep. However, no data are known about the role played by NGF in ultradian regulation in humans. The aim of this study was to investigate whether or not there is a natural diurnal fluctuation during daytime in healthy and schizophrenic subjects with a normal light/dark cycle. In a sample of 33 subjects (10 male schizophrenics and 23 healthy subjects) an ELISA assay was used to study the ultradian NGF cycle in blood samples at 9.00, 13.00 and 20.00 hours. The study showed an ultradian rhythm of NGF in healthy subjects with a "V" trend: higher at 9:00 and 20:00 and lower at 13:00. We also show significant differences between male and female controls. No NGF ultradian rhythm among schizophrenic patients compared to healthy subjects was found. The results of this study lead to a rhythmic NGF regulation that appears altered in schizophrenics, where higher levels in the morning and lower levels in the evening were observed, compared to the controls, and support the hypothesis of a role played by NGF in schizophrenia.

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Mice Lacking the p75NGFR Receptor Exhibit Abnormal Responses to Light

Cited by 12 publications

References 34 publications

Effect of 192 IgG-Saporin on Circadian Activity Rhythms, Expression of P75 Neurotrophin Receptors, Calbindin-D28K, and Light-Induced Fos in the Suprachiasmatic Nucleus in Rats

Effect of 192 IgG-Saporin on Circadian Activity Rhythms, Expression of P75 Neurotrophin Receptors, Calbindin-D28K, and Light-Induced Fos in the Suprachiasmatic Nucleus in Rats

Modulation of photic resetting in rats by lesions of projections to the suprachiasmatic nuclei expressing p75 neurotrophin receptor

Ultradian Variation of Nerve Growth Factor Plasma Levels in Healthy and Schizophrenic Subjects

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