Mice as potential carriers of infectious bursal disease virus in chickens

Park, Min Joon; Park, Jeong Ho; Kwon, Hyun-Jung

doi:10.1016/j.tvjl.2008.12.005

Cited by 9 publications

(8 citation statements)

References 6 publications

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“…(p) Surveillance of other potential reservoirs (e.g., mealworms, rodents, beetles). The available literature has shown the potential of other non-avian reservoirs (Snedeker et al, 1967;Okoye and Uche, 1986;McAllister et al, 1995;Park et al, 2010). Results would be used to determine the need for further studies, such as research on the ability of these species to transmit IBDv to poultry.…”

Section: Identify the Activitiesmentioning

confidence: 99%

A cooperative approach to animal disease response activities: Analytical hierarchy process (AHP) and vvIBD in California poultry

Saito

Shea²,

Jones

et al. 2015

Preventive Veterinary Medicine

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Section: Identify the Activitiesmentioning

confidence: 99%

A cooperative approach to animal disease response activities: Analytical hierarchy process (AHP) and vvIBD in California poultry

Saito

Shea²,

Jones

et al. 2015

Preventive Veterinary Medicine

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“…The ability of IBDV-HCV vectors to replicate in human cells ascertains the potential of IBDV to be useful as an expression vector in humans. A recent study described mice as a potential carrier for IBDV (22). The study also confirmed that IBDV maintained its viability and pathogenicity in mice and that virus excreted from mice induced clinical disease in chickens (22), suggesting that IBDV might be capable of replication in humans.…”

mentioning

confidence: 60%

“…A recent study described mice as a potential carrier for IBDV (22). The study also confirmed that IBDV maintained its viability and pathogenicity in mice and that virus excreted from mice induced clinical disease in chickens (22), suggesting that IBDV might be capable of replication in humans. Additionally, most human and animal populations are not exposed to IBDV, in contrast to vaccinia virus or adenovirus and poliovirus, on which some viral vectors and vaccines are based.…”

mentioning

confidence: 60%

Recombinant Infectious Bursal Disease Virus Carrying Hepatitis C Virus Epitopes

Upadhyay

Ammayappan

Patel

et al. 2011

J Virol

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The delivery of foreign epitopes by a replicating nonpathogenic avian infectious bursal disease virus (IBDV) was explored. The aim of the study was to identify regions in the IBDV genome that are amenable to the introduction of a sequence encoding a foreign peptide. By using a cDNA-based reverse genetics system, insertions or substitutions of sequences encoding epitope tags (FLAG, c-Myc, or hepatitis C virus epitopes) were engineered in the open reading frames of a nonstructural protein (VP5) and the capsid protein (VP2). Attempts were also made to generate recombinant IBDV that displayed foreign epitopes in the exposed loops (P BC and P HI ) of the VP2 trimer. We successfully recovered recombinant IBDVs expressing c-Myc and two different virus-neutralizing epitopes of human hepatitis C virus (HCV) envelope glycoprotein E in the VP5 region. Western blot analyses with anti-c-Myc and anti-HCV antibodies provided positive identification of both the c-Myc and HCV epitopes that were fused to the N terminus of VP5. Genetic analysis showed that the recombinants carrying the c-Myc/HCV epitopes maintained the foreign gene sequences and were stable after several passages in Vero and 293T cells. This is the first report describing efficient expression of foreign peptides from a replication-competent IBDV and demonstrates the potential of this virus as a vector. (26), has been used as a therapeutic agent without any toxicity in clinical trials with patients suffering from acute and chronic hepatitis C virus (HCV) infections (2,8). IBDV belongs to the genus Avibirnavirus of the Birnaviridae family, and its genome consists of two segments of double-stranded RNA (11). The smaller segment, B, encodes VP1, a 97-kDa multifunctional protein with polymerase and capping enzyme activities (21, 27). The larger segment, A, encodes a 110-kDa precursor polyprotein in a single large open reading frame (ORF) which is cotranslationally processed by the viral protease VP4 (4, 24) into the VP2 precursor (pVP2), VP3, and VP4. pVP2 is further processed by several proteolytic cleavages at its C terminus for conversion into mature VP2 (10). Segment A also encodes VP5, a 17-kDa nonstructural (NS) protein, in a small ORF partly preceding and overlapping the polyprotein ORF. VP5 is dispensable for viral replication in vitro and in vivo (29), which makes it a prime candidate for the construction of marked vaccines carrying deletions. These marked vectors could be easily distinguished from the wild-type virus and could also trigger a specific cellular immune response in the host species. The available structural data for VP2 (7,14,17) reveal that the protein is folded into three different domains (base B, shell S, and projection P). Expression of VP2 by itself leads to dodecahedral subviral particles (SVPs) containing 20 VP2 trimers (6) and exposing the four loops of the P domain (named P BC , P DE , P FG , and P HI ). Here, we explore the possibility of displaying foreign epitopes stably in recombinant IBDV by either inserting or replacing sequences ...

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“…Estudos anteriores têm sugerido que cães, aves selvagens, roedores e insetos podem ser importantes vetores do IBDV (HOWIE & THORSEN, 1981;MCALLISTERet al, 1995;OGAWA et al, 1998;PAGÈS-MANTÉ et al, 2004;PARK et al, 2010). A viabilidade do IBDV após passar pelo sistema digestivo de alguns animais foi demonstrada, sendo estes animais considerados portadores e/ou propagadores do IBDV (PAGÈS-MANTÉ et al, 2004;PARK et al, 2010).…”

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Anticorpos contra o vírus da Doença Infecciosa Bursal e detecção do genoma viral em criações de frango de corte e galinhas de quintal no polo avícola da Bahia

Silva

Sales

Luz³

et al. 2012

Cienc. Rural

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Mice as potential carriers of infectious bursal disease virus in chickens

Cited by 9 publications

References 6 publications

A cooperative approach to animal disease response activities: Analytical hierarchy process (AHP) and vvIBD in California poultry

A cooperative approach to animal disease response activities: Analytical hierarchy process (AHP) and vvIBD in California poultry

Recombinant Infectious Bursal Disease Virus Carrying Hepatitis C Virus Epitopes

Anticorpos contra o vírus da Doença Infecciosa Bursal e detecção do genoma viral em criações de frango de corte e galinhas de quintal no polo avícola da Bahia

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