Mice are protected against Bordetella pertussis infection by intra-nasal immunization with filamentous haemagglutinin

Cahill, E.S.

doi:10.1016/0378-1097(93)90312-p

Cited by 14 publications

(16 citation statements)

References 3 publications

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“…FHA is the dominant adhesin in Bordetella (36,55), which is a pathogen that causes respiratory tract infections in humans and animals. FHA in Bordetella pertussis is highly immunogenic in humans and is also a protective antigen in animal models (4,9,62). As in Bordetella, FHA in B. henselae may serve as a major antigenic determinant and play a role in host receptor recognition.…”

Section: Discussionmentioning

confidence: 99%

Genome Rearrangements, Deletions, and Amplifications in the Natural Population of Bartonella henselae

et al. 2006

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Cats are the natural host for Bartonella henselae, an opportunistic human pathogen and the agent of cat scratch disease. Here, we have analyzed the natural variation in gene content and genome structure of 38 Bartonella henselae strains isolated from cats and humans by comparative genome hybridizations to microarrays and probe hybridizations to pulsed-field gel electrophoresis (PFGE) blots. The variation in gene content was modest and confined to the prophage and the genomic islands, whereas the PFGE analyses indicated extensive rearrangements across the terminus of replication with breakpoints in areas of the genomic islands. We observed no difference in gene content or structure between feline and human strains. Rather, the results suggest multiple sources of human infection from feline B. henselae strains of diverse genotypes. Additionally, the microarray hybridizations revealed DNA amplification in some strains in the so-called chromosome II-like region. The amplified segments were centered at a position corresponding to a putative phage replication initiation site and increased in size with the duration of cultivation. We hypothesize that the variable gene pool in the B. henselae population plays an important role in the establishment of long-term persistent infection in the natural host by promoting antigenic variation and escape from the host immune response.

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Section: Discussionmentioning

confidence: 99%

Genome Rearrangements, Deletions, and Amplifications in the Natural Population of Bartonella henselae

et al. 2006

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“…CyaA can enter a variety of eukaryotic cell types (350). Once inside, CyaA is activated by calmodulin (830) and catalyzes the production of supraphysiologic amounts of cyclic AMP (cAMP) from ATP (89,163,164,321). Purified CyaA inhibits chemiluminescence, chemotaxis and superoxide anion generation by peripheral blood monocytes and polymorphonuclear neutrophils in vitro (611).…”

Section: Virulence Determinantsmentioning

confidence: 99%

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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Bordetella respiratory infections are common in people (B. pertussis) and in animals (B. bronchiseptica). During the last two decades, much has been learned about the virulence determinants, pathogenesis, and immunity of Bordetella. Clinically, the full spectrum of disease due to B. pertussis infection is now understood, and infections in adolescents and adults are recognized as the reservoir for cyclic outbreaks of disease. DTaP vaccines, which are less reactogenic than DTP vaccines, are now in general use in many developed countries, and it is expected that the expansion of their use to adolescents and adults will have a significant impact on reducing pertussis and perhaps decrease the circulation of B. pertussis. Future studies should seek to determine the cause of the unique cough which is associated with Bordetella respiratory infections. It is also hoped that data gathered from molecular Bordetella research will lead to a new generation of DTaP vaccines which provide greater efficacy than is provided by today's vaccines

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“…cough, produces many virulence factors (Leininger et al, 1990(Leininger et al, , 1991Relman et a[., 1989;Weiss & animal 1986). A'nurnber of these facto filamentous haemagglutinin, fimbriae, are proteins involved rs, p&tussis toxin (PT); models showed that these antigens are efficacious in pertactin (prn) and preventing B. pertussis infections, thus supporting their in intoxication and/or use in the new generation of acellular pertussis vaccines (Cahill et al, 1993;Edwards, 1993;Kimura & KunoSakai, 1990;Peppoloni et al, 1995;Shahin et al, 1990).…”

Section: Introduction Adhesion Processes Antigens Responsiblementioning

confidence: 99%

Antigenic variants in Bordetella pertussis strains isolated from vaccinated and unvaccinated children

et al. 1999

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Bordetella pertussis shows polymorphism in two proteins, pertactin (Prn) and the pertussis toxin (PT) S 1 subunit, which are important for immunity. A previous study has shown antigenic shifts in these proteins in the Dutch B. pertussis population, and it was suggested that these shifts were driven by vaccination. The recent Italian clinical trial provided the opportunity to compare the frequencies of Prn and PT 51 subunit variants in strains isolated from unvaccinated children, and from children vaccinated with two acellular and one whole-cell pertussis vaccine. Four Prn variants (Prnl, Prn2, Prn3 and Prn5) were found in the 129 strains analysed. Prnl, Prn2 and Prn3 have been described previously, whereas Prn5 is a novel variant. Prnl, Prn2, Prn3 and Prn5 were found in, respectively, 6,41, 51 and 2 % of the strains. The B. pertussis strains used to produce the vaccines administered in the clinical trial were found to produce Prnl, or a type which differed from Prnl in one amino acid. The frequency of the Prnl variant was found to be lowest in the strains isolated from vaccinated groups, suggesting that Prnl strains are more affected by vaccine-induced immunity than Prn2 and Prn3 strains. Only one PT 51 type (SlA) was observed in the examined strains, which was distinct from the types produced by the vaccine strains (SlB and SlD). The S1A type also predominates in the Dutch B. pertussis population. The genetic relationship among B. pertussis strains analysed by ISl002-based DNA fingerprinting revealed that three fingerprint types predominate, representing more than 70% of the strains. Prn2 strains showed a greater variety of fingerprint types compared to Prn3, suggesting that Prn3 has emerged more recently. The results are discussed in the light of vaccine-driven evolution.

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Mice are protected against Bordetella pertussis infection by intra-nasal immunization with filamentous haemagglutinin

Cited by 14 publications

References 3 publications

Genome Rearrangements, Deletions, and Amplifications in the Natural Population of Bartonella henselae

Genome Rearrangements, Deletions, and Amplifications in the Natural Population of Bartonella henselae

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

Antigenic variants in Bordetella pertussis strains isolated from vaccinated and unvaccinated children

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