Mica pneumoconiosis: a neglected occupational lung disease

Moitra, Subhabrata; Bandyopadhyay, A. K.; Moitra, Saibal

doi:10.1016/s2213-2600(18)30178-4

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Nevertheless, utilization of ground mica or synthesized mica products in modern cosmetics [ 12 , 13 ] implies their potential dermatological applications in treating diseases caused by microorganisms. The current study attempts to analyze the possible topical applications of selected mica-based traditional formulations, for the potential of these drugs to be developed as antimicrobial agents.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial potential of four mica drugs and their chemical and mineralogical properties

Wijenayake

Abayasekara

Pitawala

et al. 2022

BMC Complement Med Ther

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Background Mica drugs, a group of herbo-metallic traditional preparations comprising biotite mica as the major mineral ingredient, are prescribed for skin disorders and respiratory ailments and other chronic conditions in South Asian countries, particularly India and Sri Lanka. Mica-based drugs (Abhrak drugs) are subjected to unique and varied preparation procedures and the bioactivity of the drugs can be affected by drug-processing conditions, the ingredients used and the mica composition. The current study aimed to evaluate and compare, on the basis of their physical and chemical characteristics, the antimicrobial potential of two commercial mica drugs AbBb (Abhrak bhashma) and AbCh (Abhrak Chenhuram) and two mica drugs ABL1 (Abhrak Bhasma Laboratory Prepared 1) and ABL2 (Abhrak Bhasma Laboratory Prepared 2) prepared in the laboratory under different conditions. Methods Antimicrobial activity of all four drugs was assessed at 10 mg/ml concentration against Pseudomonas aeruginosa, Escherischia coli, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA) and Candida albicans using well diffusion assay, agar dilution assay and Miles and Misra method. Major and trace metal constituents of the drug samples were measured using atomic absorption spectrometry. Mineralogical properties, bacteria-mineral interactions, morphological changes in microbes and the surface characteristics of the drugs were determined using X-ray diffraction (XRD) analysis and scanning electron microscopy (SEM). Results The drugs ABL1, ABL2 and AbBh exhibited antimicrobial activity against only Gram-positive organisms (S. aureus and MRSA) when tested with Miles and Misra method (broth method). Mineralogical studies (XRD) revealed that biotite mica was altered into secondary clay minerals and iron oxides in the commercial drug AbCh while the other three drugs had altered mica and iron oxide phases. The essential elements (Na, K, Ca and Mg) required for microbial functions were present in varying extents in all four drugs while they were present in exceedingly high amounts in AbCh having comparatively high cation-exchange capacity, consistent with the observation that AbCh was inactive against all the microbes tested. The three drugs (ABL1, ABL2 and AbBh) showing antimicrobial activity contained comparatively high amounts of Fe, Zn and Cu that are known to display antimicrobial properties at high concentrations. SEM studies revealed that the drug particles adhered and entrapped the bacterial species, presumably modifying the physiochemical characteristics of the bacteria and eventually causing lethality. Conclusion Three of the four mica drugs inhibited the tested Gram-negative bacteria and the antibacterial activity of the mica drugs depends on their constituents and the methods of preparation.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial potential of four mica drugs and their chemical and mineralogical properties

Wijenayake

Abayasekara

Pitawala

et al. 2022

BMC Complement Med Ther

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“…Mica, the glitters used in cosmetics, paints, electronics, and other appliances, is mined in some developing countries where informal labourers, particularly children, are immensely exposed to this fibrogenic substance. Several reports have described the clinical and pathological features of mica pneumoconiosis [9][10][11][12] . It is also evident that the newly administered materials pose a substantial threat for humans.…”

Section: Introductionmentioning

confidence: 99%

New Occupational Exposures with Respiratory Effects

Moitra¹,

Haldar²

2021

BRN

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Occupational exposure is one of the major risk factors for lung diseases globally. Although the aetiology and the course of major occupational lung diseases are well understood, the nature of lung diseases caused by new agents is still not well evaluated. The rise of interstitial and malignant lung diseases due to occupational exposures has caught global attention because either the causal agents are novel and the mode of action is poorly understood, or classical exposures have reappeared in a newer way, or the control measures are not implemented properly. With the introduction of new and innovative technologies, new agents such as indium compounds, diketones, nanomaterials, and physical processes such as hydraulic fracking are being introduced with substantially high deliberating effects on the workers' health. In this review, we summarise some new occupational exposures contributing to respiratory diseases and provide some recommendations for reducing the burden of occupational lung diseases.

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Transcriptome analysis reveals a protective role of liver X receptor alpha against silica particle-induced experimental silicosis

Yao

Yang

et al. 2020

Science of The Total Environment

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Mica pneumoconiosis: a neglected occupational lung disease

Cited by 3 publications

References 4 publications

Antimicrobial potential of four mica drugs and their chemical and mineralogical properties

Antimicrobial potential of four mica drugs and their chemical and mineralogical properties

New Occupational Exposures with Respiratory Effects

Transcriptome analysis reveals a protective role of liver X receptor alpha against silica particle-induced experimental silicosis

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