MICA genetic polymorphism and HLA-A,C,B,MICA and DRB1 haplotypic variation in a southern Chinese Han population: Identification of two new MICA alleles, MICA*060 and MICA*062

Haplotype-Based Banking of Human Pluripotent Stem Cells for Transplantation: Potential and Limitations

“…A similar study done in China by Lin et al [51] established real ES cell lines to be used for transplantation. The prospective recipients were taken from the Hunan population, which is composed mostly of the Han ethnic group that represents about 94% of the Chinese population [52]. 174 lines resulted in a perfect match for 24.9% of the population (at the HLA-A-B-DR low resolution level), similar to the results of Taylor et al Another study in Korea reported that only 27 cell lines would give 2 mismatches or better for 16% of the population [53].…”

MICB polymorphism in a southern Chinese Han population: The identification of two new MICB alleles, MICB∗005:06 and MICB∗026

“…Maximum likelihood haplotype frequencies were estimated using the expectation-maximization (EM) algorithm, as implemented in the program ARLEQUIN 3.5. The classic coefficients of LD, D, and of normalized LD, which is also termed the relative delta value (D rel), were computed for each individual haplotype as described previously [20,[25][26][27]. Fisher's exact test was performed to determine the significance of D. The LD analysis was restricted to HLA-B-MICB, MICA-MICB haplotypes with observed frequencies >1.5%.…”

“…A total of 201 healthy, unrelated individuals of Han ethnicity recruited in Hunan province [25][26][27], were typed for MICB polymorphism in this study. This sample panel consisted of 59.2% men (119/201) and 40.8% women (82/201).…”

“…MICA, AluyMICB, and HLA data MICA, HLA-A, -C, -B and -DRB1 genes have been recently reported for the 201 samples using PCR-SBT and PCR-SSP, respectively [25][26][27]. AluyMICB insertion/deletion dimorphism has been Table 1 Primers used for PCR-SSP typing to detect the G/A dimorphism in exon 6 of MICB gene.…”

Killer cell immunoglobulin-like receptor (KIR) genes in 4 distinct populations and 51 families in mainland China

“…HLA-A,-C, and -B data have been recently reported for 201 individuals of the current sample panel of the Hunan Han population [32] and for the 104 samples of the Inner Mongolia Han population [33]. In this study, HLA-C1/C2 (Asn 80 /Lys 80 ) dimorphism was determined for the four populations using the PCR-SSP method reported by Frohn et al [34] with minor modifications.…”