Mic1‐3 Knockout ofToxoplasma gondiiIs a Successful Vaccine against Chronic and Congenital Toxoplasmosis in Mice

Abstract

Mic1-3KO is an effective vaccine against chronic and congenital toxoplasmosis.

On the Efficacy and Safety of Vaccination with Live Tachyzoites of Neospora caninum for Prevention of Neospora-Associated Fetal Loss in Cattle

“…It has been suggested based on mouse studies with Leishmania major (17) and Toxoplasma gondii (18) that induction of Th1 cytokine responses might interfere with fetal implantation and development of normal pregnancy. Since vaccination of cattle with live Neospora tachyzoites is expected to induce such cytokine responses (11,19,20), it is possible that this response to the vaccine affected the pregnancy rates in this study.…”

Induction of immune responses in sheep by vaccination with liposome-entrapped DNA complexes encoding Toxoplasma gondii MIC3 gene

“…The Mic1-3KO has been previously used in mice. This resulted in the induction of a strong humoral and cellular Th1 response and a > 96% reduction in brain tissue cysts (Ismael et al 2006). Sheep that were inoculated subcutaneously with Mic1-3KO tachyzoites showed mild febrile and IgG antibody responses.…”

Vaccines against Toxoplasma gondii: challenges and opportunities

“…After challenge with the 76K T. gondii isolate, greater than 96% reduction in the number of brain cysts, as well as reduced transmission to foetuses, was observed. In spite of these promising results, no sterile immunity was obtained (Ismael et al 2006). A review of T. gondii knock out strains used for immunization shows that although most offer protection against lethal challenge and can reduce cysts burden, some result in increased mortality (Schaap et al 2007).…”