Electro-osmotic flow via a microchannel has numerous uses in the contemporary world, including in the biochemical and pharmaceutical industries. This research explores the electroosmotic flow of Casson-type nanofluid with Sodium Alginate nanoparticles through a vertically tilted microchannel. In addition, the transverse magnetic field is also considered. In this flowing fluid, the influence of heat and mass transmission is also explored. The aforementioned physical process is represented by partial differential equations. Utilizing suitable dimensionless variables for nondimensionalized. Furthermore, the non—dimensional classical system is fractionalized with the use of generalized Fourier and Fick's law. Generalizations are made using the Caputo derivative's description. The analytical solution of the velocity, temperature, and concentration profiles is obtained by combining the methods of Laplace and Fourier. Interestingly, the influence of several physical characteristics such as the fractional parameter, Casson fluid parameter, the thermal and mass Grashof numbers, and the zeta potential parameter is displayed. Moreover, the results show that the volume fractional of nanoparticles enhances the rate of heat transfer up to 39.90%, Skin friction up to 38.05%, and Sherwood number up to 11.11%. Also, the angle of inclination enhances the fluid velocity.