MHConstructor: A high-throughput, haplotype-informed solution to the MHC assembly challenge
Kristen J. Wade,
Rayo Suseno,
Kerry Kizer
et al.
Abstract:The extremely high levels of genetic polymorphism within the human major histocompatibility complex (MHC) limit the usefulness of reference-based alignment methods for sequence assembly. We incorporate a short read de novo assembly algorithm into a workflow for novel application to the MHC. MHConstructor is a containerized pipeline designed for high-throughput, haplotype-informed, reproducible assembly of both whole genome sequencing and target-capture short read data in large, population cohorts. To-date, no … Show more
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