MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4
+
T cells in vivo
Thomas V. Guy,
Alexandra M. Terry,
Helen M. McGuire
et al.
Abstract:There has been growing interest in the role of B cells in antitumour immunity and potential use in adoptive cellular therapies. To date, the success of such therapies is limited. The intrinsic capacity of B cells to specifically activate tumour-specific CD4+ T cells
in
vivo
via TCR-dependent interactions remains poorly defined. We have developed an
in
vivo
tumour model that utilizes MHCII I-E restriction which limits antigen presentation t… Show more
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