MHC-I-presented non-canonical antigens expand the cancer immunotherapy targets in acute myeloid leukemia
Yangyang Cai,
Donghao Li,
Dezhong Lv
et al.
Abstract:Identification of tumor neoantigens is indispensable for the development of cancer immunotherapies. However, we are still lacking knowledge about the potential neoantigens derived from sequences outside protein-coding regions. Here, we comprehensively characterized the immunopeptidome landscape by integrating multi-omics data in acute myeloid leukemia (AML). Both canonical and non-canonical MHC-associated peptides (MAPs) in AML were identified. We found that the quality and characteristics of ncMAPs are compar… Show more
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