MHC class IIα polymorphism and its association with resistance/susceptibility to Vibrio harveyi in golden pompano ( Trachinotus ovatus )

Cao, Zhenjie; Wang, Lu; Xiang, Yajing; Liu, Xiaocen; Tu, Zhigang; Sun, Yun; Zhou, Yongcan

doi:10.1016/j.fsi.2018.06.020

Cited by 7 publications

(3 citation statements)

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“…Eight of the 13 IIA data sets from fish were from hatchery or aquaculture settings, where the high density of a single fish species and the spatial overlap of adults and juveniles can set the stage for more pronounced disease transmission (Krkošek et al, 2006 ; Pulkkinen et al, 2010 ). If enough time elapses, the resulting pathogen‐mediated selection on MHC (Cao et al, 2018 ; Yang et al, 2016 ) might not only alter allele frequencies of standing genetic variation, but also lead to signals of positive selection. There might also be direct artificial selection for parasite‐resistant traits in aquaculture species (Kube et al, 2012 ), given that the proportion of farmed or domesticated species in our data set was somewhat higher in fish (8 of 13 species) than in mammals (9 of 31 species).…”

Section: Discussionmentioning

confidence: 99%

Meta‐analysis of major histocompatibility complex (MHC) class IIA reveals polymorphism and positive selection in many vertebrate species

2022

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Across jawed vertebrates, the genes of the major histocompatibility complex (MHC) make cell-surface proteins that display pathogen peptides to the immune system (Murphy & Weaver, 2017). The MHC is central to host-pathogen interactions, and different MHC alleles encode proteins that can differ in their effectiveness against particular pathogens (Sepil et al., 2013;Wegner et al., 2003). This makes MHC variation a key component of host-parasite dynamics

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Section: Discussionmentioning

confidence: 99%

Meta‐analysis of major histocompatibility complex (MHC) class IIA reveals polymorphism and positive selection in many vertebrate species

2022

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“…In pompano, 29 alleles of the Trov-MHC II gene with high polymorphism have been identified. The similarity of the amino acid sequences between the Trov-MHC IIα gene and the HLA II, DM α-chain precursor (NCBI reference sequence: NP_006111.2) in humans and the MHC IIα genes in other fish species is in a range between 27.6% and 78.6% (4). These studies have also demonstrated that the Trov-DAA * 6401 and Trov-DAA * 6702 alleles are linked to fish immunity to infection with Vibrio harveyi, whereas the Trov-DAA * 6304 and Trov-DAA * 7301 alleles are, in contrast, connected with fish susceptibility to infection with these bacteria.…”

Section: Mhc Class II Molecules In Osteichthyesmentioning

confidence: 99%

Major histocompatibility complex in Osteichthyes

Stosik

Tokarz–Deptuła

Deptuła

2020

Journal of Veterinary Research

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Based on analysis of available genome sequences, five gene lineages of MHC class I molecules (MHC I-U, -Z, -S, -L and -P) and one gene lineage of MHC class II molecules (MHC II-D) have been identified in Osteichthyes. In the latter lineage, three MHC II molecule sublineages have been identified (MHC II-A, -B and -E). As regards MHC class I molecules in Osteichthyes, it is important to take note of the fact that the lineages U and Z in MHC I genes have been identified in almost all fish species examined so far. Phylogenetic studies into MHC II molecule genes of sublineages A and B suggest that they may be descended from the genes of the sublineage named A/B that have been identified in spotted gar (Lepisosteus oculatus). The sublineage E genes of MHC II molecules, which represent the group of non-polymorphic genes with poor expression in the tissues connected with the immune system, are present in primitive fish, i.e. in paddlefish, sturgeons and spotted gar (Lepisosteus oculatus), as well as in cyprinids (Cyprinidae), Atlantic salmon (Salmo salar), and rainbow trout (Oncorhynchus mykiss). Full elucidation of the details relating to the organisation and functioning of the particular components of the major histocompatibility complex in Osteichthyes can advance the understanding of the evolution of the MHC molecule genes and the immune mechanism.

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“…Notwithstanding the important economic significance of golden pompano, basic research including molecular breeding, immunology, evolutionary biology, and molecular-genetic association studies in this species remain largely unexplored due to the lack of high-quality genomic data and accurate gene annotations. Fortunately, some molecular markers have recently been developed 13,14 . However, there is only limited information on important economic traits, such as growth, disease resistance, and reproduction, owing to the shortage of genetic information in golden pompano.…”

Section: Introductionmentioning

confidence: 99%

Golden pompano genome resource enables discovery of valuable gene determining growth traits

Luo

Zhang

et al. 2021

Preprint

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One important goal of fish genetic breeding is to identify valuable loci and genes that can facilitate growth and thereby productivity. Few such loci or genes have been identified in golden pompano (Trachinotus ovatus), a species of significant economic value. In this study, we produced a high-quality chromosome-level genome assembly of the golden pompano by de novo sequencing and assemblies for 2 parents and 200 F1 offspring by genome re-sequencing. We exploited these assemblies to identify loci and genes by QTL mapping, Kompetitive Allele Specific PCR (KASP) genotyping, and haplotype-based regional association analysis based on growth records of a 64 biparental and 147 individuals from a naturally occurring population. At a locus 291kb from BSNP21031, we identified a somatostatin receptor type 1-like (designated as gpsstr1) gene in which the BSNP1369 of the promoter region was highly associated with growth. Loss of sstr1a, the homolog of gpsstr1 in zebrafish, caused growth retardation. Sstr1a mediated growth via sstr2 and Wnt-gsk-3β signaling pathways. Our findings provide new insights into the underlying mechanisms controlling growth. Our strategy can serve as an effective way to uncover novel genomic information and facilitate improvement of fish growth.

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MHC class IIα polymorphism and its association with resistance/susceptibility to Vibrio harveyi in golden pompano ( Trachinotus ovatus )

Cited by 7 publications

References 62 publications

Meta‐analysis of major histocompatibility complex (MHC) class IIA reveals polymorphism and positive selection in many vertebrate species

Meta‐analysis of major histocompatibility complex (MHC) class IIA reveals polymorphism and positive selection in many vertebrate species

Major histocompatibility complex in Osteichthyes

Golden pompano genome resource enables discovery of valuable gene determining growth traits

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