MHC class II peptides induce CD8+CD44+Ly49+ regulatory T cells in C57BL/6 mice

Yao, Yunliang; Wang, Xiang; Zhang, Hui; Shi, Yue; Wang, Shiyu; Wang, Xiaoyi

doi:10.1016/j.cellimm.2016.11.005

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…The role of Ly49 + CD8 T-cells in the immune system is uncertain. Several authors suggest that Ly49 + CD8 T-cells have immunosuppressive properties ( 11 , 12 , 29 , 30 ). At the same time, other studies suggest that CD8 T-cells upregulate Ly49 receptors as a response to TCR or cytokine stimulation under certain conditions, either because of exposure to autoantigens ( 10 , 16 ) or during the antiviral response ( 13 , 15 , 31 , 32 ).…”

Section: Discussionmentioning

confidence: 99%

“…The major factors affecting the upregulation of Ly49 receptors by CD8 T-cells include the immune response and STAT1 signaling ( 10 , 13 , 15 , 16 , 31 ). Immunization with MHC class II-restricted antigens also facilitates the upregulation of Ly49 receptors on CD8 T-cells, which suggests interactions with some other cells, presumably with activated T-cells ( 11 , 12 , 30 ). Further, some studies propose the involvement of CD4 T-cells as well as CD4 T-regs in the induction or survival of Ly49 + CD8 T-cell ( 10 , 42 ).…”

Section: Discussionmentioning

confidence: 99%

“…Murine Ly49 + CD8 T-cells also represent memory T-cells (2,10), but their biological functions are contradictory. Several studies report these cells to have efficient immunosuppressive capacities (11,12), while other studies demonstrate the participation of Ly49 + CD8 T-cells in the immune response and the ability to lyse virus-infected target cells (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

“…Factors driving the expression of Ly49 receptors on CD8 Tcells are not defined yet. Numerous experiments describe the upregulation of Ly49 receptors on CD8 T-cells as a result of stimulation with the cognate antigen (either during the infection or during the exposure to self-antigens) (10,16,17), cytokines (18,19), or because of interactions with activated lymphocytes during the immune response (presumably, activated CD4 Tcells) (10)(11)(12). However, the exact cellular or molecular mechanisms that govern this process, as well as the stability of Ly49 expression with time, are unknown.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Functional Characterization of Ly49+CD8 T-Cells in Both Normal Condition and During Anti-Viral Response

Shytikov

Rohila

et al. 2021

Front. Immunol.

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The role of Ly49+CD8 T-cells in the immune system is not clear. Previously, several papers suggested Ly49+CD8 T-cells as immunosuppressors, while multiple studies also suggested their role as potent participants of the immune response. The mechanism of Ly49 expression on CD8 T-cells is also not clear. We investigated phenotype, functions, and regulation of Ly49 expression on murine CD8 T-cells in both normal state and during LCMV infection. CD8 T-cells express different Ly49 receptors compared with NK-cells. In intact mice, Ly49+CD8 T-cells have a phenotype similar to resting central memory CD8 T-cells and do not show impaired proliferation and cytokine production. Conventional CD8 T-cells upregulate Ly49 receptors during TCR-induced stimulation, and IL-2, as well as IL-15, affect it. At the same time, Ly49+CD8 T-cells change the Ly49 expression profile dramatically upon re-stimulation downregulating inhibitory and upregulating activating Ly49 receptors. We observed the expression of Ly49 receptors on the virus-specific CD8 T-cells during LCMV infection, especially marked in the early stages, and participation of Ly49+CD8 T-cells in the anti-viral response. Thus, CD8 T-cells acquire Ly49 receptors during the T-cell activation and show dynamic regulation of Ly49 receptors during stimulation.

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