1996
DOI: 10.1016/s1074-7613(00)80255-1
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MHC Class I–Restricted CTL Responses to Exogenous Antigens

Abstract: reactivity in F1 (A ϫ B) hosts. Although the mode of transfer of antigenic material from the transplanted, im-and Jo ¨rg Reimann † munogenic cells to host-derived APC during cross-prim-*Microbiology and Tumor Biology Center ing has not been elucidated, recent evidence for the Karolinska Institute shedding of antigenic vesicles (Zhou et al., 1992a; Ra-S-171 77 Stockholm poso et al., 1996) and for the release of immunogenic, Sweden apoptotic blebs (Casciola-Rosen et al., 1996) provides † Institute of Medical Mic… Show more

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Cited by 239 publications
(155 citation statements)
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“…A special compartment for processing of extracellular antigen for MHC class I expression in antigen-presenting cells, mostly phagocytic cells, was described to be endolysosomal [6][7][8][9]. The presence of internalized antigen together with MHC class I and class II molecules in a compartment similar to the classical low pH MHC class II processing compartment (MIIC) was demonstrated [25].…”
Section: Discussionmentioning
confidence: 99%
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“…A special compartment for processing of extracellular antigen for MHC class I expression in antigen-presenting cells, mostly phagocytic cells, was described to be endolysosomal [6][7][8][9]. The presence of internalized antigen together with MHC class I and class II molecules in a compartment similar to the classical low pH MHC class II processing compartment (MIIC) was demonstrated [25].…”
Section: Discussionmentioning
confidence: 99%
“…The presence of internalized antigen together with MHC class I and class II molecules in a compartment similar to the classical low pH MHC class II processing compartment (MIIC) was demonstrated [25]. MHC class I molecules can enter this compartment either via the ER or through recycling from the cell surface and can then bind processed peptides through peptide exchange [7,9]. Many different cell types express an alternative MHC class I processing pathway, but there is comparatively little information regarding DC.…”
Section: Discussionmentioning
confidence: 99%
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“…Through this mechanism, class I-restricted CD8 + CTL is activated by corresponding exogenous ( foreign ) antigens. 18,19 This type of antigen -presentation pathway is called an alternative MHC class I pathway. DCs play the important role as APCs in cross -priming, 20 and cross -priming of CTL requires CD4 + T cells.…”
Section: Discussionmentioning
confidence: 99%