MHC class I and II peptide homology regulates the cellular immune response

Halpert, Matthew M.; Konduri, Vanaja; Liang, Dan; Vazquez‐Perez, Jonathan; Hofferek, Colby J.; Weldon, Scott A.; Baig, Yunyu; Vedula, Indira; Levitt, Jonathan M.; Decker, William K.

doi:10.1096/fj.201903002r

Cited by 8 publications

(7 citation statements)

References 79 publications

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“…In previous studies, we observed a significant upregulation in the number of peripheral CD8 + NK1.1 + cells following administration of a T H 1 polarized dendritic cell vaccine (50)(51)(52)(53). In mice, TGF-b is reported to repress the differentiation of NK1.1 + T cells from CD8 + T cells.…”

Section: Cd8 + Nk11 + T Cells Are Protective Against Viral Infections and Intracellular Pathogensmentioning

confidence: 85%

CD8+CD161+ T-Cells: Cytotoxic Memory Cells With High Therapeutic Potential

et al. 2021

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NK1.1 and its human homolog CD161 are expressed on NK cells, subsets of CD4+ and CD8+ T cells, and NKT cells. While the expression of NK1.1 is thought to be inhibitory to NK cell function, it is reported to play both costimulatory and coinhibitory roles in T-cells. CD161 has been extensively studied and characterized on subsets of T-cells that are MR1-restricted, IL-17 producing CD4+ (TH17 MAIT cells) and CD8+ T cells (Tc17 cells). Non-MAIT, MR1-independent CD161-expressing T-cells also exist and are characterized as generally effector memory cells with a stem cell like phenotype. Gene expression analysis of this enigmatic subset indicates a significant enhancement in the expression of cytotoxic granzyme molecules and innate like stress receptors in CD8+NK1.1+/CD8+CD161+ cells in comparison to CD8+ cells that do not express NK1.1 or CD161. First identified and studied in the context of viral infection, the role of CD8+CD161+ T-cells, especially in the context of tumor immunology, is still poorly understood. In this review, the functional characteristics of the CD161-expressing CD8+ T cell subset with respect to gene expression profile, cytotoxicity, and tissue homing properties are discussed, and application of this subset to immune responses against infectious disease and cancer is considered.

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Section: Cd8 + Nk11 + T Cells Are Protective Against Viral Infections and Intracellular Pathogensmentioning

confidence: 85%

CD8+CD161+ T-Cells: Cytotoxic Memory Cells With High Therapeutic Potential

et al. 2021

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“…Considering previous publications ( 15 , 28 ), there are at least three aspects associated with immune status: HLA gene expression, DNA damage and immunogenicity. HLA (human leukocyte antigen) on the surface of many immune cells plays an important role in activating cellular and humoral immunity ( 29 ). We compared HLA gene expression among the three classes and found that all HLA genes were expressed at a high level in the Immunity-H group and at a low level in the Immunity-L group (P<0.001) ( Figure 2A ), validating that the absence of the HLA gene contributed to the low immune status.…”

Section: Resultsmentioning

confidence: 99%

Immune Cluster and PPI Network Analyses Identified CXCR3 as a Key Node of Immunoregulation in Head and Neck Cancer

Wang

Jiang

et al. 2021

Front. Oncol.

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The tumor microenvironment (TME) is significantly associated with clinical outcomes and therapeutic efficacy. However, the landscape of the head and neck cancer (HNC) microenvironment is not fully understood. Therefore, we divided HNCs into three classes according to differences in the TME to determine effective personalized treatments. We explored the immune landscape of head and neck cancer by analysing the gene expression profile of 501 cases from the Cancer Genome Atlas (TCGA) data portal and validated our findings in 270 cases from the Gene Expression Omnibus (GEO) database. The levels of immune components in the tumor microenvironment were evaluated via single-sample gene set enrichment (ssGSEA) analysis. The HNCs were clustered into an Immunity-H group, Immunity-M group and Immunity-L group according to 40 immune components in the tumor microenvironment. DNA damage and HLA genes play an important role in immune regulation. The patients in the Immunity-H group had a favourable survival compared with patients in the Immunity-M group and the Immunity-L group. The patients in the Immunity-H group and Immunity-M group could benefit from radiotherapy. In addition, the Immunity-L group showed the lowest immunophenoscore and had poor response to anti-PD-1 treatment. CXCR3 was demonstrated to be downregulated in the Immunity-L group, which was related to shorter OS in the TCGA and GEO databases, suggesting CXCR3 as a potential therapeutic target. Taken together, our findings proposed three new microenvironment-related phenotypes of HNCs and suggested that CXCR3 played a major role in immune regulation and could be a novel therapeutic target, providing a reference for clinical decisions and research directions in the future.

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“…Rab-GTPase also regulates the entry and transport of HPV to the nucleus [ 27 ]. AIMP1 may regulate antiviral immunity and polarizes immunity towards Th1 polarization [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in the Proteome in the Development of Chronic Human Papillomavirus Infection—A Prospective Study in HIV Positive and HIV Negative Rwandan Women

Bienvenu

Mukanyangezi

Rulisa

et al. 2021

Cancers

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Background: Effects on the proteome when a high risk (HR)-HPV infection occurs, when it is cleared and when it becomes chronic were investigated. Moreover, biomarker panels that could identify cervical risk lesions were assessed. Methods: Cytology, HPV screening and proteomics were performed on cervical samples from Rwandan HIV+ and HIV- women at baseline, at 9 months, at 18 months and at 24 months. Biological pathways were identified using the String database. Results: The most significantly affected pathway when an incident HR-HPV infection occurred was neutrophil degranulation, and vesicle-mediated transport was the most significantly affected pathway when an HR-HPV infection was cleared; protein insertion into membrane in chronic HR-HPV lesions and in lesions where HR-HPVs were cleared were compared; and cellular catabolic process in high-grade lesions was compared to that in negative lesions. A four-biomarker panel (EIF1; BLOC1S5; LIMCH1; SGTA) was identified, which was able to distinguish chronic HR-HPV lesions from cleared HR-HPV/negative lesions (sensitivity 100% and specificity 91%). Another four-biomarker panel (ERH; IGKV2-30; TMEM97; DNAJA4) was identified, which was able to distinguish high-grade lesions from low-grade/negative lesions (sensitivity 100% and specificity 81%). Conclusions: We have identified the biological pathways triggered in HR-HPV infection, when HR-HPV becomes chronic and when cervical risk lesions develop. Moreover, we have identified potential biomarkers that may help to identify women with cervical risk lesions.

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MHC class I and II peptide homology regulates the cellular immune response

Cited by 8 publications

References 79 publications

CD8+CD161+ T-Cells: Cytotoxic Memory Cells With High Therapeutic Potential

CD8+CD161+ T-Cells: Cytotoxic Memory Cells With High Therapeutic Potential

Immune Cluster and PPI Network Analyses Identified CXCR3 as a Key Node of Immunoregulation in Head and Neck Cancer

Changes in the Proteome in the Development of Chronic Human Papillomavirus Infection—A Prospective Study in HIV Positive and HIV Negative Rwandan Women

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