MHC antigens on human tumors

Ruiz‐Cabello, Francisco; Klein, E.; Garrido, Federico

doi:10.1016/0165-2478(91)90168-a

Cited by 51 publications

(32 citation statements)

References 59 publications

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“…A large body of work in experimental models supports the idea that both the qualitative and quantitative expression of major histocompatibility complex products can affect immune responses [6][7][8]. Several reports have shown that the reduction or loss of H-2 cell surface antigens can contribute to increased malignancy of an antigenic tumor, presumably through escape from T cells [6][7][8][9].…”

Section: Discussionmentioning

confidence: 90%

“…Haywood and McKhann [5] further investigated this question in 3-methylcholanthrene-induced tumors, with the observation that fibrosarcomas with high H-2 expression were more prone to spread to the lungs than tumors of low H-2 expression. Other reports have added further evidence of the influence of these antigens [6][7][8][9]. The MHC-associated control of metastasis has been discussed mainly in relation to the induction of and escape from T cells, but MHC complex may also be influenced in vivo by other types of interactions involving the NK system [10,11].…”

Section: Introductionmentioning

confidence: 99%

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In vivo activation of NK cells induces inhibition of lung colonization of H-2 positive and H-2 negative fibrosarcoma tumor clones

et al. 1994

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The role of different tilorone analogs in the abrogation of the metastatic spread of H-2 positive and H-2 negative tumor clones was studied. Pre-treatment of BALB/c mice with RMI 10,874DA compound completely abolished lung colonization of an H-2 negative (GR9.B9) MCA-induced fibrosarcoma clone in an experimental metastasis assay. This effect was also evident when clones were treated with other tilorone analogs (R11,567DA or R11,513DA). Other H-2 positive and H-2 negative chemically induced fibrosarcoma clones were also tested. The effect was not due to direct toxicity of the tilorone analog on tumor cells, but instead was dependent on NK cells; this was suggested by the finding that treatment of mice with anti-asialo GM1 abrogated the effect of the tilorone analog (RMI 10,874DA compound). Interestingly, the inhibition of lung colonization after intravenous injection was again observed regardless of the H-2 phenotype of the tumor clones, and H-2+ and H-2- clones were similarly inhibited. In vitro assays of NK sensitivity of tumor clones showed that lysis varied depending on the H-2 phenotype of tumor clones, indicating an absence of correlation between in vivo and in vitro results.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

In vivo activation of NK cells induces inhibition of lung colonization of H-2 positive and H-2 negative fibrosarcoma tumor clones

et al. 1994

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“…55 The expression of HLA class I and class II may be reduced, thus inhibiting recognition by donor T cells. 56 Other explanations could be insufficient expression of adhesion molecules and low production of proinflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Leukemia lineage-specific chimerism analysis is a sensitive predictor of relapse in patients with acute myeloid leukemia and myelodysplastic syndrome after allogeneic stem cell transplantation

et al. 2001

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One of the major complications after allogeneic stem cell transplantation (SCT) in patients with malignant disease is a high frequency of relapse. We have prospectively analyzed the clinical impact of recipient-derived chimeric cells in 30 patients with acute myeloid leukemia and myelodysplastic syndrome after SCT. In order to improve sensitivity and specificity, all samples were cell-separated by using immunomagnetic beads according to the patient's leukemia phenotype, expressed at diagnosis or relapse before SCT. Twelve out of 30 patients experienced a clinical relapse after SCT. Median follow-up time for patients alive and without relapse (n = 15) was 30 (16-47) months. Mixed chimerism in peripheral blood (PB) and bone marrow (BM) у1 month post SCT, in the leukemia-affected cell lineage, was detected in 14/30 patients. Ten of these 14 patients relapsed as compared to 2/16 with donor chimerism (DC) (P Ͻ0.01). All eight patients with MC in peripheral blood у1 month after SCT relapsed vs 4/22 DC patients (P Ͻ 0.001). MC was detected a median of 66 (23-332) days before hematological relapse. No correlation was found between T cell MC and relapse. In this study, chimerism analysis showed a higher sensitivity and specificity vs morphological examination. In conclusion, this study may provide a rational basis for treatment with adoptive immunotherapy at an earlier time after SCT than at present, in patients with AML and MDS, in order to treat recurrences of malignant disease. Leukemia (2001Leukemia ( ) 15, 1976Leukemia ( -1985

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“…MHC class I (MHC-1) pref erably presents endogenous antigen to cytotoxic CD8-positive T cells (CTLs). MHC-I molecules were expressed on most nucleated cells and are associated with (32-micro globulin [7], Reduced expression or lack of MHC-I ex pression can render cells non-immunogenic to CTLs and may provide a way for cells to escape CTL-mediated destruction [8], Reduced expression or lack of MHC-I has been found in a variety of human cancers arising from different sites of the body [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

β2-Microglobulin and HLA-DR Expression in Relation to the Presence of Epstein-Barr Virus in Nasopharyngeal Carcinomas

et al. 1995

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We have investigated the immunohistochemical expression of β 2-microglobulin and HLA-DR proteins in nasopharyngeal carcinoma (NPC) in relation to the expression of the Epstein-Barr virus (EBV)-encoded EBER 1-2 mRNAs and LMP-1 protein. β2-Microglobulin is expressed in association with MHC-I molecules on most nucleated cells and HLA-DR belongs to the MHC-II molecules which are expressed mostly on antigen-presenting cells. Formalin-fixed paraffin-embedded tissue from 37 NPC cases was stained with immunohistochemistry for β 2-microglobulin, HLA-DR and LMP-1 proteins and by RNA in situ hybridization for EBER 1-2 mRNAs. β 2-Microglobulin-positive staining was found in neoplastic cells in all cases. In 19/37 NPC cases the positive staining was found in most neoplastic cells. In the remaining 18 NPC cases more than 25% of the neoplastic cells showed significantly reduced or negative staining in comparison to the normal epithelium and infiltrating small lymphocytes. HLA-DR-positive staining was found in 27/37 NPC cases. EBER 1 -2 transcripts were deteced in neoplastic cells in 13/37 NPC cases. LMP-1 expression in tumour cells was found in 4/13 EBERl-2-positive cases. No correlation was found between the presence of EBER 1-2 transcripts or LMP-1 protein and the β 2-microglobulin-reduced expression in NPC. Thus, EBV does not seem to use downregulation of MHC-I to avoid the T cell cytotoxic immune response in NPC. HLA-DR expression was observed in all 13 EBV-positive cases of NPC, suggesting that EBV may participate in the induction of HLA-DR expression in a proportion of NPC.

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MHC antigens on human tumors

Cited by 51 publications

References 59 publications

In vivo activation of NK cells induces inhibition of lung colonization of H-2 positive and H-2 negative fibrosarcoma tumor clones

In vivo activation of NK cells induces inhibition of lung colonization of H-2 positive and H-2 negative fibrosarcoma tumor clones

Leukemia lineage-specific chimerism analysis is a sensitive predictor of relapse in patients with acute myeloid leukemia and myelodysplastic syndrome after allogeneic stem cell transplantation

β2-Microglobulin and HLA-DR Expression in Relation to the Presence of Epstein-Barr Virus in Nasopharyngeal Carcinomas

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MHC antigens on human tumors

Cited by 51 publications

References 59 publications

In vivo activation of NK cells induces inhibition of lung colonization of H-2 positive and H-2 negative fibrosarcoma tumor clones

In vivo activation of NK cells induces inhibition of lung colonization of H-2 positive and H-2 negative fibrosarcoma tumor clones

Leukemia lineage-specific chimerism analysis is a sensitive predictor of relapse in patients with acute myeloid leukemia and myelodysplastic syndrome after allogeneic stem cell transplantation

&beta;2-Microglobulin and HLA-DR Expression in Relation to the Presence of Epstein-Barr Virus in Nasopharyngeal Carcinomas

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β2-Microglobulin and HLA-DR Expression in Relation to the Presence of Epstein-Barr Virus in Nasopharyngeal Carcinomas