mGluR1 in the fundic glands of rat stomach

Gabriel, Ana Maria San; Maekawa, Takuji; Uneyama, Hisayuki; Souma, Yoshie; Torii, Kunio

doi:10.1016/j.febslet.2007.02.016

Cited by 103 publications

(80 citation statements)

References 27 publications

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“…For example, neuronal glutamate receptors such as metabotropic glutamate type 1 (mGluR1) and type 4 (mGluR4) are expressed in the taste cells on the tongue 1 3) as well as mucosal cells in the stomach and duodenum 4,5) . Sweet taste receptors (T1R2/T1R3) and umami taste receptors (T1R1/ T1R3) for sensing amino acids on the tongue have also been indicated to be distributed in the intestine.…”

Section: Amino Acid-sensing Receptors Distrib-uted In the Taste And Gmentioning

confidence: 99%

Nutritional and Physiological Significance of Luminal Glutamate-sensing in the Gastrointestinal Functions

Uneyama

2011

YAKUGAKU ZASSHI

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Recent evidence indicates that free amino acids are nutrients as well as acting as chemical transmitters within the gastrointestinal tract. Gut glutamate research is the most advanced among 20 amino acids. Free glutamate carries the umami taste sensation on the tongue and a visceral sensation in the gut, especially the stomach. In theˆeld of taste physiology, the physiological meaning of the glutamate-derived chemical sense, the umami taste, has been proposed to be a marker of protein intake. Experimental evidence in gut glutamate physiology strongly supports this hypothesis. Free glutamate is sensed by the abdominal vagus and regulates gastrointestinal functions such as secretion and emptying to accelerate protein digestion. Clinical application of glutamate has also just begun to treat gastrointestinal disorders such as dyspepsia, ulcer, dry mouth and functional dyspepsia. In this review, we introduce recent advances in gut glutamate research and consider the possible contribution of glutamate to health.

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Section: Amino Acid-sensing Receptors Distrib-uted In the Taste And Gmentioning

confidence: 99%

Nutritional and Physiological Significance of Luminal Glutamate-sensing in the Gastrointestinal Functions

Uneyama

2011

YAKUGAKU ZASSHI

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“…Infusion of amino acids into the intestine has been shown to increase vagal afferent activity and antroduodenal contraction (25). Interestingly, two groups of researchers have reported that T1Rs and mGluR1, receptors mediating the umami taste in the oral cavity, are expressed in the GI mucosa of humans, rats, and mice (26,27). Intragastric administration of L-glutamate increases the firing rate of afferent fibers running in the gastric branch of the vagus nerve in rats (28).…”

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confidence: 99%

New Frontiers in Gut Nutrient Sensor Research: Monosodium L-Glutamate Added to a High-Energy, High-Protein Liquid Diet Promotes Gastric Emptying: a Possible Therapy for Patients With Functional Dyspepsia

et al. 2010

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Abstract. Functional dyspepsia is a clinical syndrome that features abdominal symptoms centered in the upper abdomen without an organic basis. Three possible mechanisms of gastric dysfunction could be related to functional dyspepsia: 1) delayed gastric emptying, 2) impaired gastric accommodation to food intake, and 3) hypersensitivity to gastric distention. Delayed gastric emptying has been suggested to lead to prolonged antral distension that causes dyspeptic symptoms. Delayed gastric emptying is therefore a focal point of debate about anorexia caused by dyspepsia, and prokinetic agents are often administered in Japan for its treatment. Recently, we found that addition of monosodium L-glutamate (MSG) to a high-energy liquid diet rich in casein promoted gastric emptying in healthy men. Therefore, another potential method to improve delayed gastric emptying could be enhancement of chemosensors that activate the autonomic nervous system innervating the gastrointestinal tract. In conclusion, enrichment with glutamate promoted gastric emptying after intake of a high-protein meal, suggesting that free glutamate is important for protein digestion and that MSG may be helpful for management of delayed gastric emptying in patients with functional dyspepsia.

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“…mGluR4 is localized at low expression levels in the rat jejunum (14). In contrast, mGluR1 is located in the chief cells (pepsinogen-secreting cells) of the rat stomach (15). In addition, some mGluRs and amino acids sensors are expressed in gastric mucosal cells using cell fractions isolated from rats (16,17).…”

Section: Gut Nutrient Stimuli Regulate Autonomic Nervous System Activitymentioning

confidence: 99%

New Therapeutic Strategy for Amino Acid Medicine: Effects of Dietary Glutamate on Gut and Brain Function

et al. 2012

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Abstract. The gustatory and visceral stimulation from food regulates digestion and nutrient utilization, and free glutamate (Glu) release from food is responsible for the umami taste perception that increases food palatability. The results of recent studies reveal a variety of physiological roles for Glu. For example, luminal applications of Glu into the mouth, stomach, and intestine increase the afferent nerve activities of the glossopharyngeal nerve, the gastric branch of the vagus nerve, and the celiac branch of the vagus nerve, respectively. Additionally, luminal Glu evokes efferent nerve activation of each branch of the abdominal vagus nerve. The intragastric administration of Glu activates several brain areas (e.g., insular cortex, limbic system, and hypothalamus) and has been shown to induce flavor-preference learning in rats. Functional magnetic resonance imaging of rats has shown that the intragastric administration of Glu activates the nucleus tractus solitarius, amygdala, and lateral hypothalamus. In addition, Glu may increase flavor preference as a result of its postingestive effect. Considering these results, we propose that dietary Glu functions as a signal for the regulation of the gastrointestinal tract via the gut-brain axis and contributes to the maintenance of a healthy life.

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mGluR1 in the fundic glands of rat stomach

Cited by 103 publications

References 27 publications

Nutritional and Physiological Significance of Luminal Glutamate-sensing in the Gastrointestinal Functions

Nutritional and Physiological Significance of Luminal Glutamate-sensing in the Gastrointestinal Functions

New Frontiers in Gut Nutrient Sensor Research: Monosodium L-Glutamate Added to a High-Energy, High-Protein Liquid Diet Promotes Gastric Emptying: a Possible Therapy for Patients With Functional Dyspepsia

New Therapeutic Strategy for Amino Acid Medicine: Effects of Dietary Glutamate on Gut and Brain Function

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