Mg-substituted hydroxyapatite nanopowders: Synthesis, thermal stability and sintering behaviour

Cacciotti, Ilaria; Bianco, Alessandra; Lombardi, Mariangela; Montanaro, Laura

doi:10.1016/j.jeurceramsoc.2009.04.038

Cited by 237 publications

(183 citation statements)

References 29 publications

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“…Also, its rapid rate of surface reactions, which leads to fast tissue bonding, is another advantage of hydroxyapatite [30]. Therefore, when the n-HA/PA66 cage is used as an implant in the human body, it induces the strong bond to bone and enhances the bone tissue in growth; also stimulates the osteoblast proliferation and differentiation in vitro.…”

Section: Discussionmentioning

confidence: 99%

Improving the Mechanical Properties and Apatite Formation Ability of Nano-Hydroxyapatite/Polyamide 66 Composite for Using as the Intervertebral Fusion Cage

Janghorban¹

2017

Jour. Mater. Sci. Eng. Adv. Tech.

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One of the significant challenges in designing an ideal cage is the mechanical modulus mismatch between the implant and surrounding host tissue which results in stress shielding. In this study, a nano-hydroxyapatite/polyamide 66 (n-HA/PA66) composite with mechanical properties close to spongy bone to be designed and characterized as an intervertebral fusion cage to perform spinal fusion between vertebrae in the lumbar spine. A pure natural nanohydroxyapatite (n-HA) powder was prepared by annealing bovine bone at 1000°C followed by 10h mechanical alloying. The nano-hydroxyapaptite/ polyamide 66 and polyamide 66 (PA66) cage were prepared by injection method. X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive spectrophotometer (EDS) were used to characterize the powder and composites samples. The results showed that addition of 20% nanohydroxyapaptite results in the improvement of both mechanical and bioactivity properties. The optimum n-HA/PA66 exhibited the compressive strength and elastic modulus of 46.98 ± 2MPa and 1.53 ± 0.3GPa, respectively, which is close HAMID REZA JANGHORBAN 22 to spongy bone. In addition, observation of the superior apatite formation ability of n-HA/PA66 compared to PA66 indicates that it can be used as a bone replacement material.

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Section: Discussionmentioning

confidence: 99%

Improving the Mechanical Properties and Apatite Formation Ability of Nano-Hydroxyapatite/Polyamide 66 Composite for Using as the Intervertebral Fusion Cage

Janghorban¹

2017

Jour. Mater. Sci. Eng. Adv. Tech.

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“…In vivo studies have demonstrated that the presence of Mg in HA improves cell behaviour, adhesion with synthetic hard tissues, proliferation, and metabolic activation [12]. For these reasons, Mg is an interesting element to study regarding its possible ionic substitutions into the HA structure [3,[13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Low-temperature densification of Mg-doped hydroxyapatite fine powders under hydrothermal hot processing conditions

Montoya-Cisneros

Rendón-Ángeles

Matamoros-Veloza

et al. 2017

Ceramics International

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Abstract:Densification of calcium hydroxyapatite fine powders doped with different concentrations of Mg (2, 4 and 6 mol % Mg, MgHA) was successfully achieved for the first time in a nearly fully dense state using the 2 hydrothermal hot pressing (HHP) technique at low temperatures. Consolidation of MgHA powders was studied under different temperatures (150-240 ºC), reaction times (1-6 h), and powder particle size (20 nm-1.5 m). X-Ray diffraction analyses indicated that the particle densification under HHP conditions proceeded without any variation in the crystalline structure and regardless of the Mg content. The results from this work showed that an increase in temperature accelerates the reaction between MgHA particles and water (solvent) mixed during the hydrothermal treatment. Particle packing associated with bulk densification was achieved through a massive dissolution-recrystallisation mechanism, which induced the formation of small particles that rapidly crystallised on the surface of the partially dissolved original MgHA particles. The optimum conditions to obtain pellets with a high apparent density of 3.0758 ± 0.001 g/cm 3 and tensile strength value of 12.6 ± 0.6 MPa were 10 wt% of water at a temperature of 240 ºC with a 6 h reaction time and 6 mol % of Mg (MgHA3). The use of the HHP technique coupled with the fine particle size and reactivity of the MgHA precursor powders with water allowed us to produce disks that were compacted to a nearly full dense state with a low content of open porosity of 2.0 %.

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“…Metal ions in bone tissue have been proven to play an active role in promoting bone mineralization and angiogenesis [3,4]. However, for the synthetic HA, only Ca、P、O and H elements remain in the crystal structure, showing a higher stability than that of natural apatite.…”

Section: Introductionmentioning

confidence: 99%

Structural Analysis and Characterization of Cu, Sr-doped Hydroxyapatite Whiskers

Guo¹,

Wen²,

Zhang³

et al. 2015

Proceedings of the 2015 International Conference on Materials, Environmental and Biological Engineering

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Abstract.Cu and Sr ions doped hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HA) whiskers were synthesized by hydrothermal homogeneous precipitation method. The morphology, structure and the phase composites of the products were characterized by XRD, FTIR and SEM. The results showed that Cu 2+ or Sr 2+ partially substituted for Ca 2+ in the HA crystal, resulting in lattice distortion and lower crystallinity with Sr or Cu addition. For Cu-doped HA (Cu-HA) whiskers, the doping limit proportion should be below 8mol%, and for Sr-doped HA whiskers (Sr-HA), it was below 20mol%.

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Mg-substituted hydroxyapatite nanopowders: Synthesis, thermal stability and sintering behaviour

Cited by 237 publications

References 29 publications

Improving the Mechanical Properties and Apatite Formation Ability of Nano-Hydroxyapatite/Polyamide 66 Composite for Using as the Intervertebral Fusion Cage

Improving the Mechanical Properties and Apatite Formation Ability of Nano-Hydroxyapatite/Polyamide 66 Composite for Using as the Intervertebral Fusion Cage

Low-temperature densification of Mg-doped hydroxyapatite fine powders under hydrothermal hot processing conditions

Structural Analysis and Characterization of Cu, Sr-doped Hydroxyapatite Whiskers

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