Mg–1Zn–1Ca alloy for biomedical applications. Influence of the secondary phases on the mechanical and corrosion behaviour

Pulido-González, N.; Torres, B.; García-Rodríguez, S.; Rodrigo, P.; Bonache, V.; Hidalgo-Manrique, P.; Mohedano, M.; Rams, J.

doi:10.1016/j.jallcom.2020.154735

Cited by 43 publications

(15 citation statements)

References 65 publications

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“…Natural bone [61] -E = 20-25 GPa UTS = 180-270 MPa Mg1Zn1Ca [62] Indirect chill casting E = 54.4 GPa 4.39 -Mg1.73Zn1.54Y [63] Extrusion UTS = 266 MPa 2.827 -MgZn [64] Extrusion UTS = 236 MPa --MgFe [65] Sputtering E = 123 GPa 7.6 -Zn0.5Mg [66] Furnace heating UTS = 102 MPa 9.5 Yes Mg3Ca [67] Casting UTS = 118 MPa 14.5 -Mg3Ca2Zn [67] Casting UTS = 145 MPa 3.86 -MgAl alloy (AZ91) [68] Casting of MgZnCe is low without any surface modification or coating in this work. Novel strategies could be developed to reduce it further in the future, along with the excellent mechanical properties and cytocompatibility it offers to engineer implants.…”

Section: Methodsmentioning

confidence: 99%

Zinc and cerium synergistically enhance the mechanical properties, corrosion resistance, and osteogenic activity of magnesium as resorbable biomaterials

et al. 2021

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Magnesium and its alloys have the potential to serve as a revolutionary class of biodegradable materials, specifically in the field of degradable implants for orthopedics. However, the corrosion rate of commercially pure magnesium is high and does not match the rate of regeneration of bone tissues. In this work, magnesium alloys containing zinc and cerium, either alone or in combination, were investigated and compared with commercially-pure magnesium as biomaterials. The microstructure, mechanical properties, corrosion resistance, and response of osteoblasts in vitro were systematically assessed. Results reveal that alloying with Ce results in grain refinement and weakening of texture. The tensile test revealed that the ternary alloy offered the best combination of elastic modulus (41.1 ± 0.5 GPa), tensile strength (234.5 ± 4.5 MPa), and elongation to break (17.1 ± 0.4%). The ternary alloy was also the most resistant to corrosion (current of 0.85 ± 0.05 × 10−4 A cm−2) in simulated body fluid than the other alloys. The response of MC3T3-E1 cells in vitro revealed that the ternary alloy imparts minimal cytotoxicity. Interestingly, the ternary alloy was highly efficient in supporting osteogenic differentiation, as revealed by the expression of alkaline phosphatase and calcium deposition. In summary, the extruded Mg alloy containing both Zn and Ce exhibits a combination of mechanical properties, corrosion resistance, and cell response that is highly attractive for engineering biodegradable orthopedic implants.

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Section: Methodsmentioning

confidence: 99%

Zinc and cerium synergistically enhance the mechanical properties, corrosion resistance, and osteogenic activity of magnesium as resorbable biomaterials

et al. 2021

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“…The intrinsic degradation resistance primarily depends on the electrode potential of Mg-based alloy, oxidation layer property, and galvanic-corrosion tendency, which are determined by the physicochemical properties including impurity contents [11] and alloying elements [29][30][31][32], microstructure (e.g. grain size and second phase, segregation, and intragranular misorientation) [22,[33][34][35][36][37][38][39], plastic deformation [40], internal stress [41,42] and so on. Surface treatment or modification, which is common in medical implants [43], can also modulate the degradation rate of the Mg-based alloys by retarding [44] or accelerating [45] degradation reactions.…”

Section: General Degradation Mechanismsmentioning

confidence: 99%

Biodegradable Mg-based alloys: biological implications and restorative opportunities

Lin

Saijilafu

et al. 2022

International Materials Reviews

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Mg-based alloys as revolutionary implantable biomaterials have increasingly attracted considerable attention, owing to their biodegradability in vivo and beneficial effects on biological systems. The degradation process and products of Mg-based alloys have been reported to exhibit significant biological effects on host-tissue responses. However, these effects have not yet been fully understood. This review systemically summarizes and analyses the current understandings and recent research progress in this area. The primary focal points are the biological effects and related mechanisms associated with the degradation behaviour of Mg-based alloys. The biological impacts of the degradation products are elucidated and the arguable or controversial issues are also discussed, providing a pathway toward a greater understanding of the biological implications of Mg-based alloys. Furthermore, based on these biological implications, the restorative potential of Mg-based alloys for applications in tissue repair and regeneration is summarized. Finally, outlooks on biosafety evaluation and design strategies for Mg-based alloy implants are briefly discussed.

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“…Adding alloy elements may change the chemical components of magnesium alloy directly or indirectly and drive change in its form of organization, and the second phase size and distribution, consequently improving the corrosion resistance behavior of magnesium alloy [90,91] . On the other hand, grain size of magnesium alloy can be reduced by alloying [92] and plastic deformation [93] , so that mechanical properties of alloys can be improved effectively.…”

Section: Mg 2clmentioning

confidence: 99%

Research Progress on Corrosion Resistance of Magnesium Alloys with Bio-inspired Water-repellent Properties: A Review

Cai

Lian

et al. 2021

J Bionic Eng

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Thanks to its excellent mechanical properties, magnesium alloys have many potential applications in the aerospace and other fields. However, failure to adequately solve corrosion problems of magnesium alloy becomes one of the factors restricting its wide use in many industrial fields. Inspired by nature, researchers designed and fabricated bio-inspired water-repellent (superhydrophobic and slippery liquid-infused porous surface) surfaces with special wetting properties by exploring the surface microstructures of plants and animals such as lotus leaf and nepenthes pitcher, exhibiting excellent corrosion-resistant performance. This article summarizes the research progress on corrosion resistance of magnesium alloys with bio-inspired water-repellent properties in recent years. It mainly introduces the corrosion reasons, types of corrosion of magnesium alloys, and the preparation of magnesium alloys with bio-inspired water-repellent properties to improve corrosion resistance. In particular, it is widely used and effective to construct water-repellent and anti-corrosion coating on the surface of magnesium alloy by surface treatment. It is hoped that the research in this review can broaden the application range of magnesium alloys and provide a powerful reference for the future research on corrosion resistance of magnesium alloys.

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Mg–1Zn–1Ca alloy for biomedical applications. Influence of the secondary phases on the mechanical and corrosion behaviour

Cited by 43 publications

References 65 publications

Zinc and cerium synergistically enhance the mechanical properties, corrosion resistance, and osteogenic activity of magnesium as resorbable biomaterials

Zinc and cerium synergistically enhance the mechanical properties, corrosion resistance, and osteogenic activity of magnesium as resorbable biomaterials

Biodegradable Mg-based alloys: biological implications and restorative opportunities

Research Progress on Corrosion Resistance of Magnesium Alloys with Bio-inspired Water-repellent Properties: A Review

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