MFAE: Multilevel Feature Aggregation Enhanced Drug‐Target Affinity Prediction for Drug Repurposing Against Colorectal Cancer
Guanxing Chen,
Haohuai He,
Calvin Yu-Chian Chen
Abstract:Colorectal cancer (CRC), a leading cause of cancer‐related deaths globally, demands innovative therapeutic strategies to improve patient outcomes. Drug repurposing, identifying new uses for existing drugs, provides a cost‐effective solution. To this end, this study constructs the first drug‐target affinity dataset specifically for two novel therapeutic targets for CRC, P2X4 and mTOR, and designs a new deep learning‐based multilevel feature aggregation enhanced (MFAE) model. The model implements hierarchical fe… Show more
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