Mexoryl® SX: a broad absorption UVA filter protects human skin from the effects of repeated suberythemal doses of UVA

Nitroxides and a nitroxide-based UV filter have the potential to photoprotect UVA-irradiated human skin fibroblasts against oxidative damage

“…ROS production in fibroblasts was initially established using moderate UVA doses of up to 18 J/cm 2 by measuring the fluorescence emitted from the oxidized carboxy-H 2 DCFDA ROSindex probe. This is a biologically relevant dose equivalent to that received by human skin exposed to clear midday, midsummer sun, for a short period of time [28,29]. The results reported in Fig.…”

An organotypic model of skin to study photodamage and photoprotection in vitro

“…Data obtained in reconstructed skin in vitro were, thus, in agreement with studies performed in vivo with the same sunscreen formulations. 17,22,23 …”

Efficacy of Sunscreens Containing Pre-Tocopheryl in a Surviving Human Skin Model Submitted to UVA and B Radiation

“…The cream 50B-10A containing or not pre-tocopheryl was applied to the epidermis. Then UV radiation was performed as previously described [10] in order to rapidly induce damages to the fi brous components of the dermis as those observed in vivo [11,12] . The source of UV radiation was a Vilbert Lourmat stimulator (France) fi tted out with a UVB irradiation source composed of Vilbert Lourmat tubes T-15.M-312 (no UVA, no UVC emission), a UVA irradiation source composed of Vilbert Lourmat tubes T-15.L-365 (no UVB, no UVC emission), mercury vapour tubes, low pressure, and hot cathodes with a Vilbert Lourmat RMX-365/312 radiometer with a programmable microprocessor (measuring energy, in mJ/cm 2 ) and a time basis enabling 6 irradiation measurements per second for the control of energy received by the skin fragment.…”