Mexican American Children Have Differential Elevation of Metabolic Biomarkers Proportional to Obesity Status

McFarlin, Brian K.; Johnson, Craig A.; Moreno, Jennette P.; Foreyt, John P.

doi:10.1097/mpg.0b013e3182a6993d

Cited by 19 publications

(14 citation statements)

References 20 publications

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“…In the case of the present study, reduced IL-12p70 with probiotic supplementation may reflect a reduction in systemic inflammatory capacity. In addition to the biomarkers that reached significance, we also found similar numerical trends for IL-6, IL-8, and MCP-1, which are all released by adipose tissues and commonly elevated in obese individuals[ 27 , 31 , 39 ]. The biomarkers observed to change in the present study following the probiotic intervention are involved in the accumulation of systemic inflammation[ 38 , 40 - 43 ].…”

Section: Discussionsupporting

confidence: 53%

Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers

McFarlin

Henning

Bowman

et al. 2017

WJGP

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AIMTo determine if 30-d of oral spore-based probiotic supplementation could reduce dietary endotoxemia.METHODSApparently healthy men and women (n = 75) were screened for post-prandial dietary endotoxemia. Subjects whose serum endotoxin concentration increased by at least 5-fold from pre-meal levels at 5-h post-prandial were considered “responders” and were randomized to receive either placebo (rice flour) or a commercial spore-based probiotic supplement [Bacillus indicus (HU36), Bacillus subtilis (HU58), Bacillus coagulans, and Bacillus licheniformis, and Bacillus clausii] for 30-d. The dietary endotoxemia test was repeated at the conclusion of the supplementation period. Dietary endotoxin (LAL) and triglycerides (enzymatic) were measured using an automated chemistry analyzer. Serum disease risk biomarkers were measured using bead-based multiplex assays (Luminex and Milliplex) as secondary, exploratory measures.RESULTSData were statistically analyzed using repeated measures ANOVA and a P < 0.05. We found that spore-based probiotic supplementation was associated with a 42% reduction in endotoxin (12.9 ± 3.5 vs 6.1 ± 2.6, P = 0.011) and 24% reduction in triglyceride (212 ± 28 vs 138 ± 12, P = 0.004) in the post-prandial period Placebo subjects presented with a 36% increase in endotoxin (10.3 ± 3.4 vs 15.4 ± 4.1, P = 0.011) and 5% decrease in triglycerides (191 ± 24 vs 186 ± 28, P = 0.004) over the same post-prandial period. We also found that spore-based probiotic supplementation was associated with significant post-prandial reductions in IL-12p70 (24.3 ± 2.2 vs 21.5 ± 1.7, P = 0.017) and IL-1β (1.9 ± 0.2 vs 1.6 ± 0.1, P = 0.020). Compared to placebo post supplementation, probiotic subject had less ghrelin (6.8 ± 0.4 vs 8.3 ± 1.1, P = 0.017) compared to placebo subjects.CONCLUSIONThe key findings of the present study is that oral spore-based probiotic supplementation reduced symptoms indicative of “leaky gut syndrome”.

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Section: Discussionsupporting

confidence: 53%

Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers

McFarlin

Henning

Bowman

et al. 2017

WJGP

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“…Previously reported associations between metabolic and inflammatory biomarkers and body composition variables (Eriksson et al, 2010;Larsson et al, 2011;McFarlin et al, 2013;Pedrosa et al, 2011;Roth & Reinehr, 2010) were confirmed also in this study cohort, with the exception of the reported inverse association between total adiponectin and indices of body composition and anthropometrics (Eriksson et al, 2010;Pedrosa et al, 2011). We analysed the HMW isoform of adiponectin, which is reported to be more strongly associated with insulin resistance and the metabolic syndrome than total adiponectin concentrations (Hirose et al, 2010).…”

Section: Discussionsupporting

confidence: 50%

“…Elevated insulin and C-peptide levels are connected to diabetes risk as they indicate metabolic disturbances of glucose sensitivity (McFarlin et al, 2013). In our study population, metabolic biomarker response patterns were identified, where C-peptide was normal in overweight children but elevated in the obese while leptin was elevated in overweight children and then further elevated in the obese.…”

Section: Discussionmentioning

confidence: 88%

Impact of probiotics during weaning on the metabolic and inflammatory profile: follow-up at school age

Videhult

Andersson

Öhlund

et al. 2015

International Journal of Food Sciences and Nutrition

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We hypothesised that feeding the probiotic Lactobacillus paracasei ssp. paracasei F19 (LF19) (dep. nr LMG P-17806) during weaning would program the metabolic and inflammatory profile and studied its association with previously assessed body composition. In a double-blind, placebo-controlled trial, 179 infants were randomised to daily feeding of cereals with or without LF19 10(8) CFU from 4 to 13 months of age. At age 8-9 years, 120 children were re-assessed. Using high-sensitivity multiplex immunoassay technology and ELISA, we found that overweight/obese children had increased plasma C-peptide, plasminogen activator inhibitor-1, leptin and serum high-sensitivity C-reactive protein (hsCRP) after overnight fasting compared with normal weight children, independently of LF19. After excluding the obese, leptin and hsCRP were still increased, revealing an aberrant metabolic and inflammatory state already in overweight, pre-pubertal children. Higher body mass index z-score, sagittal abdominal diameter, truncal and total body fat % were associated with an aberrant metabolic and inflammatory profile, emphasising the need for early prevention strategies although no programming effect of LF19 was observed.

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“…Studies have analyzed the relationship between these hormones or cytokines and metabolic risk factors according to children's weight status [ 7 , 9 , 10 ]. But few studies have reported the concomitant variations of these factors after a lifestyle intervention [ 7 , 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Ghrelin, adipokines, metabolic factors in relation with weight status in school-children and results of a 1-year lifestyle intervention program

et al. 2015

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BackgroundOverweight in Guadeloupe is a public health matter affecting children and adults. In the present study we evaluated the metabolic profile, including serum ghrelin, leptin and adiponectin levels, in normal weight, overweight and obese school children and we analyzed the potential changes in anthropometric and metabolic risk factors after a 1-year lifestyle intervention program.MethodsParameters were assessed at baseline and at 1 year. Three groups (G) were defined according the International Obesity Task Force reference values, G1: normal weight / G2: overweight / G3: obese. The lifestyle intervention included dietary counseling, regular physical activity and family support.ResultsA total of 120 children (G1: n = 44, G2: n = 39, G3: n = 37), aged 11– 15 years and 59 % girls were enrolled. Obese children showed significant lower HDL-C, adiponectin and ghrelin concentrations, higher triglycerides, fasting blood glucose, insulin and leptin levels and also higher frequencies of abdominal obesity (G1: 2.3 %, G2: 28.2 %, G3: 73 %) and insulin resistance (GI: 39 %, G2: 72 %, G3: 89 %) than the other groups. In the overall sample, the linear regressions exploring the associations of ghrelin, adiponectin and leptin with age, gender, BMI z-score, HOMA-IR and tanner stage as independent variables showed strong associations of leptin levels with weight status and insulin resistance at baseline. The models accounted for 58 % of variability in leptin levels compared with 26 and 15 % for adiponectin and ghrelin levels respectively.In 83 children who completed the program, significant decreases in BMI z-score in overweight and obese children were noted. Leptin levels decreased significantly only in the obese group whereas adiponectin concentrations increased significantly in the three groups,In obese children, a significant correlation was found between changes in BMI Z-score, and changes in leptin levels (r = 0.39; P = 0.049) but not with changes in adiponectin levels.ConclusionsAbdominal obesity and insulin resistance were highly prevalent in obese children highlighting their risk of metabolic complications in adulthood. A 1-year long lifestyle intervention was associated with improvement in BMI z-score and metabolic parameters.

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Mexican American Children Have Differential Elevation of Metabolic Biomarkers Proportional to Obesity Status

Abstract: We observed that Mexican American children as a function of body weight had elevated serum concentrations of several biomarkers that have been linked to chronic disease development in adults. More research is needed to understand how these differences affect disease risk in adulthood.

Cited by 19 publications

References 20 publications

Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers

Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers

Impact of probiotics during weaning on the metabolic and inflammatory profile: follow-up at school age

Ghrelin, adipokines, metabolic factors in relation with weight status in school-children and results of a 1-year lifestyle intervention program

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