METTL3 drives heart failure by regulating Spp1 and Fos m6A modification in myocardial infarction
Hao Cheng,
Linnan Li,
Yufei Zhou
et al.
Abstract:While m6A modification has been reported in myocardial infarction (MI), the detailed mechanism by which METTL3 regulates the progression of the disease has not yet been elucidated, and it remains unclear why m6A modification increases after MI. Through MeRIP-seq and extensive bioinformatics analysis, the target genes SPP1 and FOS with the most significant m6A modification and differential expression in MI were screened. We successfully constructed heart specific Mettl3 knockout mice (Mettl3CKO) to verify that … Show more
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