Metronomic cyclophosphamide and metformin inhibited tumor growth and repopulated tumor infiltrating lymphocytes in experimental carcinoma model
Heba M Zaki,
Khadiga M Ali,
Mona Y Y Abd Allah
et al.
Abstract:Metformin is a widely used antidiabetic biguanide. Retrospective data demonstrated the association of metformin use with survival benefit in multiple tumor types. Interest in repurposing metformin to treat cancer has not been translated into encouraging clinical benefit. In animal models, metformin activated cytotoxic T cells and exerted an immune-mediated anticancer effect. The current research was conducted to investigate the possible therapeutic benefit of metformin in combination with metronomic cyclophosp… Show more
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