Metronidazole

Bucklin, Mason H.; Groth, Christine M.; Henriksen, Brian

doi:10.1016/b978-0-12-386454-3.00751-x

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…Cocrystals between two compounds with benefits for humans, such as pharmaceutical and nutraceutical active ingredients, are currently explored as a strategy to generate potential synergetic health benefits . In this sense, a cocrystal between theophylline (a methylxanthine compound, used to treat asthma, which can be found in foods such as tea, coffee, or chocolate) and pterostilbene (a phytoalexin present in fruits such as grapes, deerberries, blueberries, peanuts, with preventive and therapeutic properties in human diseases) , is a potential candidate for bringing together in a single solid form several health benefits simultaneously. Although a relevant body of knowledge about intermolecular interactions is available for the scientific community to design new cocrystals, strategies based on aromatic interactions are usually less followed than those based on the most easily predicted hydrogen bonds .…”

Section: Introductionmentioning

confidence: 99%

DFT Analysis of Uncommon π···H-Bond Array Interaction in a New Pterostilbene/Theophylline Cocrystal

Bofill¹,

Prohens

Barbas

et al. 2020

Crystal Growth & Design

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A new cocrystal formed between the nutraceutical compounds pterostilbene and theophylline was synthesized and X-ray characterized in the form of a dichloromethane solvate. An interesting supramolecular assembly is formed by means of a combination of common and uncomment π−π and Hbonding interactions. It was computationally studied by a combination of density functional theory (DFT), quantum theory of "atoms-in-molecules", and noncovalent interaction plot approaches, and the analyses revealed a π(C C)•••H-bond array interaction, which is the first description of this type of interaction where the donor π-system is a double bond. The participation of the cocrystallized CH 2 Cl 2 solvent molecule in Cl•••Cl and C−H•••π interactions was also studied using DFT and Hirshfeld surface calculations. The Cambridge structural database was inspected to investigate whether the π•••H-bond array interaction is common in other theophylline cocrystals. Other examples where the π-system of an aromatic ring or an amido group interact with the H-bond array were found in literature and further discussed herein.

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Section: Introductionmentioning

confidence: 99%

DFT Analysis of Uncommon π···H-Bond Array Interaction in a New Pterostilbene/Theophylline Cocrystal

Bofill¹,

Prohens

Barbas

et al. 2020

Crystal Growth & Design

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“…Metronidazole (MNZ) is a nitroimidazole derivative and has been widely used for the treatment of protozoal diseases including Giardia infections, amebic liver abscess, bacterial vaginosis 1 2 , etc. In general, MNZ is also employed for any potentially susceptible anaerobic infection by veterinary community or as a promoter to induce the growth of aquatic products 3 4 5 . However, MNZ has been banned by many countries and areas from use in food producing animals 6 due to its carcinogenic properties according to the WHO International Agency for Research on Cancer (IARC) 7 .…”

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confidence: 99%

Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors

Liu

et al. 2015

Sci Rep

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Electrochemical nanosensors based on nanoporous gold leaf (NPGL) and molecularly imprinted polymer (MIP) are developed for pharmaceutical analysis by using metronidazole (MNZ) as a model analyte. NPGL, serving as the loading platform for MIP immobilization, possesses large accessible surface area with superb electric conductivity, while electrochemically synthesized MIP thin layer affords selectivity for specific recognition of MNZ molecules. For MNZ determination, the hybrid electrode shows two dynamic linear range of 5 × 10−11 to 1 × 10−9 mol L−1 and 1 × 10−9 to 1.4 × 10−6 mol L−1 with a remarkably low detection limit of 1.8 × 10−11 mol L−1 (S/N = 3). In addition, the sensor exhibits high binding affinity and selectivity towards MNZ with excellent reproducibility and stability. Finally, the reliability of MIP-NPGL for MNZ detection is proved in real fish tissue samples, demonstrating the potential for the proposed electrochemical sensors in monitoring drug and biological samples.

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“…Metronidazole (MNZ) is a nitroimidazole derivative and has been widely applied in human beings, animals, and fish for curing protozoal and bacterial diseases. − In addition, it is also used as a promoter to induce the growth of aquatic products. , However, because MNZ shows genotoxic, carcinogenic, and mutagenic side effects, , its application in aquaculture and farming industries has been prohibited by many countries and areas. , Thus, the accurate determination of trace levels of MNZ is necessary in various samples. Different methods have been reported for detecting MNZ, such as spectrophotometry, , thin-layer chromatography, gas chromatography, high-performance liquid chromatography (HPLC), and electrochemistry. ,,− Some of these strategies suffer from disadvantages including the involvement of time-consuming manipulation steps, requirement of sophisticated equipment and skilled operators, consumption of a large amount of organic reagent, etc. , Among them, an electroanalytical sensing technique has been proven to be an attractive route owing to its high sensitivity, simplicity, rapid analysis period, and low-cost apparatus. ,,− …”

Section: Introductionmentioning

confidence: 99%

Novel Electrochemical Sensing Platform Based on a Molecularly Imprinted Polymer Decorated 3D Nanoporous Nickel Skeleton for Ultrasensitive and Selective Determination of Metronidazole

Liu

Yang

et al. 2015

ACS Appl. Mater. Interfaces

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A novel electrochemical sensor has been developed by using a composite element of three-dimensional (3D) nanoporous nickel (NPNi) and molecularly imprinted polymer (MIP). NPNi is introduced in order to enhance the electron-transport ability and surface area of the sensor, while the electrosynthesized MIP layer affords simultaneous identification and quantification of the target molecule by employing Fe(CN)6(3-/4-) as the probe to indicate the current intensity. The morphology of the hybrid film was observed by scanning electron microscopy, and the properties of the sensor were examined by cyclic voltammetry and electrochemical impedance spectroscopy. By using metronidazole (MNZ) as a model analyte, the sensor based on the MIP/NPNi hybrid exhibits great features such as a remarkably low detection limit of 2 × 10(-14) M (S/N = 3), superb selectivity in discriminating MNZ from its structural analogues, and good antiinterference ability toward several coexisting substances. Moreover, the proposed method also demonstrates excellent repeatability and stability, with relative standard deviations of less than 1.12% and 1.4%, respectively. Analysis of MNZ in pharmaceutical dosage form and fish tissue is successfully carried out without assistance of complicated pretreatment. The MIP/NPNi composite presented here with admirable merits makes it a promising candidate for developing electrochemical sensor devices and plays a role in widespread fields.

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Metronidazole

Cited by 5 publications

References 4 publications

DFT Analysis of Uncommon π···H-Bond Array Interaction in a New Pterostilbene/Theophylline Cocrystal

DFT Analysis of Uncommon π···H-Bond Array Interaction in a New Pterostilbene/Theophylline Cocrystal

Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors

Novel Electrochemical Sensing Platform Based on a Molecularly Imprinted Polymer Decorated 3D Nanoporous Nickel Skeleton for Ultrasensitive and Selective Determination of Metronidazole

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