Metronidazole Therapy for Cutaneous Leishmaniasis

Pedersen, James K.

doi:10.1001/archderm.1975.01630220107012

Cited by 20 publications

(3 citation statements)

References 5 publications

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“…Among the 10 molecules used to fight Leishmania , only three were classified as inactive: Metronidazole, Allopurinol, and Pentoxifylline. Beneficial treatment of Leishmania with these drugs has been reported in some studies − but it is controversial in others. − For instance, combinations of pentavalent antimonials with oral allopurinol have been effective in the treatment of L. major lesions and leishmaniasis recidivans caused by L.…”

Section: Resultsmentioning

confidence: 99%

“…tropica, respectively . Metronidazole, orally administered or injected intralesionally, has been effective in the treatment of cutaneous leishmaniasis. ,, In spite of these positive findings, there are reports about the inefficacy of these three compounds. − For instance, it is stated by Mapar and Omidian that intralesional Metronidazole injections have little effect for the treatment of cutaneous leishmaniasis . Walton et al reported serious doubts about the efficacy of Metronidazole as well.…”

Section: Resultsmentioning

confidence: 99%

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A Novel Automated Framework for QSAR Modeling of Highly Imbalanced Leishmania High-Throughput Screening Data

Casanova-Alvarez

Helguera

Cabrera‐Pérez

et al. 2021

J. Chem. Inf. Model.

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In silico prediction of antileishmanial activity using quantitative structure−activity relationship (QSAR) models has been developed on limited and small datasets. Nowadays, the availability of large and diverse high-throughput screening data provides an opportunity to the scientific community to model this activity from the chemical structure. In this study, we present the first KNIME automated workflow to modeling a large, diverse, and highly imbalanced dataset of compounds with antileishmanial activity. Because the data is strongly biased toward inactive compounds, a novel strategy was implemented based on the selection of different balanced training sets and a further consensus model using single decision trees as the base model and three criteria for output combinations. The decision tree consensus was adopted after comparing its classification performance to consensuses built upon Gaussian-Naıve-Bayes, Support-Vector-Machine, Random-Forest, Gradient-Boost, and Multi-Layer-Perceptron base models. All these consensuses were rigorously validated using internal and external test validation sets and were compared against each other using Friedman and Bonferroni−Dunn statistics. For the retained decision tree-based consensus model, which covers 100% of the chemical space of the dataset and with the lowest consensus level, the overall accuracy statistics for test and external sets were between 71 and 74% and 71 and 76%, respectively, while for a reduced chemical space (21%) and with an incremental consensus level, the accuracy statistics were substantially improved with values for the test and external sets between 86 and 92% and 88 and 92%, respectively. These results highlight the relevance of the consensus model to prioritize a relatively small set of active compounds with high prediction sensitivity using the Incremental Consensus at high level values or to predict as many compounds as possible, lowering the level of Incremental Consensus. Finally, the workflow developed eliminates human bias, improves the procedure reproducibility, and allows other researchers to reproduce our design and use it in their own QSAR problems.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Novel Automated Framework for QSAR Modeling of Highly Imbalanced Leishmania High-Throughput Screening Data

Casanova-Alvarez

Helguera

Cabrera‐Pérez

et al. 2021

J. Chem. Inf. Model.

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“…Up to now there has not been a single satisfactory treatment for cutaneous leishmaniasis: pentavalent antimonials, amphotericin B, antimalarials, pentamidine, 4–8 and more recently metronidazole, 9,10 rifampicin, 5,11,12 and curettage with electrodesiccation 13 have been used. Cryotherapy has been used as a mode of treatment; 4,6,8,14,15 these lesions were treated with carbon dioxide snow 8,14,15 .…”

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confidence: 99%

CRYO CORNER: Cryosurgery for Cutaneous Leishmaniasis

Faber¹

1983

The Journal of Dermatologic Surgery and Oncology

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Cutaneous leishmaniasis: surgical management of a case with unusual clinical and histological features

Barsky¹

1978

Archives of Dermatology

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Our case of cutaneous leishmaniasis clinically resembles the atypical form "infiltrees en nappes" that was described by Photinos in 1930. A subsequent biopsy of the lesion was performed more than one year after its onset and after a full course of stibogluconate sodium and the specimen showed multiple organisms in multinucleated giant cells as well as in histiocytes. Electrodesiccation and curettage of the lesion resulted in complete healing with minimal scarring.

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Metronidazole Therapy for Cutaneous Leishmaniasis

Cited by 20 publications

References 5 publications

A Novel Automated Framework for QSAR Modeling of Highly Imbalanced Leishmania High-Throughput Screening Data

A Novel Automated Framework for QSAR Modeling of Highly Imbalanced Leishmania High-Throughput Screening Data

CRYO CORNER: Cryosurgery for Cutaneous Leishmaniasis

Cutaneous leishmaniasis: surgical management of a case with unusual clinical and histological features

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