Metronidazole Susceptibility in Clostridium difficile Isolates Recovered from Cases of C. difficile -associated Disease Treatment Failures and Successes

Sanchez, Jason L.; Gerding, Dale N.; Olson, Mary M.

doi:10.1006/anae.1999.0268

Cited by 20 publications

(9 citation statements)

References 6 publications

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“…Similar observations of a reduced initial response to metronidazole and increased recurrent CDI were also reported in Quebec, Canada (155). Notably, however, while there have been occasional reports of resistance to metronidazole (CLSI breakpoint of 32 mg/liter) (12,27,149,150,178,179,216), metronidazole treatment failure has not been linked to antimicrobial resistance in C. difficile (172). Several recent reports have highlighted that the epidemiology of metronidazole susceptibility in C. difficile may have changed.…”

Section: Susceptibility Of C Difficile To Metronidazole and Vancomycinmentioning

confidence: 59%

The Changing Epidemiology of Clostridium difficile Infections

et al. 2010

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SUMMARY The epidemiology of Clostridium difficile infection (CDI) has changed dramatically during this millennium. Infection rates have increased markedly in most countries with detailed surveillance data. There have been clear changes in the clinical presentation, response to treatment, and outcome of CDI. These changes have been driven to a major degree by the emergence and epidemic spread of a novel strain, known as PCR ribotype 027 (sometimes referred to as BI/NAP1/027). We review the evidence for the changing epidemiology, clinical virulence and outcome of treatment of CDI, and the similarities and differences between data from various countries and continents. Community-acquired CDI has also emerged, although the evidence for this as a distinct new entity is less clear. There are new data on the etiology of and potential risk factors for CDI; controversial issues include specific antimicrobial agents, gastric acid suppressants, potential animal and food sources of C. difficile, and the effect of the use of alcohol-based hand hygiene agents.

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Section: Susceptibility Of C Difficile To Metronidazole and Vancomycinmentioning

confidence: 59%

The Changing Epidemiology of Clostridium difficile Infections

et al. 2010

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“…22,29e32 Recurrences, however, may occur after infection with any strain; there is little evidence to suggest that in vitro resistance to metronidazole (or vancomycin) explains treatment failures or recurrences. 33 Secondly, successful treatment of the recurrent episode is often followed by another recurrence. In one study of 209 patients with recurrent CDI, the successful treatment of all episodes required an average of 265 additional days/patient of vancomycin and 19.7 days/patient of metronidazole.…”

Section: Treatmentmentioning

confidence: 99%

Recurrent Clostridium difficile infection: A review of risk factors, treatments, and outcomes

Johnson

2009

Journal of Infection

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326

245

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“…Moreover, recent studies have reported high failure rates of metronidazole 75 76. Although resistance to metronidazole has been reported,77 78 clinical CDAD treatment failures with this antibiotic may not be attributable to decreased susceptibility of the causative C difficile isolate to metronidazole 79…”

Section: Medical Treatmentmentioning

confidence: 99%

Recent advances in Clostridium difficile-associated disease

Monaghan

Boswell

Mahida

2009

Postgraduate Medical Journal

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The main purpose of this article is to review recent developments in the management of acute and recurrent Clostridium difficile-associated disease, with consideration of existing and new antibiotic and non-antibiotic agents for treatment. Details of the current developmental stage of new agents are provided and the role of surgery in the management of severe disease is discussed. Infection control measures considered comprise prudent use of antimicrobials, prevention of cross-infection and surveillance. Other topics that are covered include the recent emergence of an epidemic hypervirulent strain, pathogenesis, clinical presentation and approaches to rapid diagnosis and assessment of the colonic disease.

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Metronidazole Susceptibility in Clostridium difficile Isolates Recovered from Cases of C. difficile -associated Disease Treatment Failures and Successes

Cited by 20 publications

References 6 publications

The Changing Epidemiology of Clostridium difficile Infections

The Changing Epidemiology of Clostridium difficile Infections

Recurrent Clostridium difficile infection: A review of risk factors, treatments, and outcomes

Recent advances in Clostridium difficile-associated disease

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