Metronidazole ototoxicity - report of two cases

Objective To review current information about diagnosis and management of tinnitus aiming to identify opportunities for achieving a cost-effective, efficient, evidence-based approach that meets the needs of tinnitus sufferers. Data Sources PubMed/MEDLINE. Review Methods In total, 249 relevant published reports were reviewed. Pertinent keywords and MeSH terms identified reports via PubMed and EMBASE. Acknowledged experts were consulted on ways to improve tinnitus management. Conclusions There may be opportunities to improve evaluation and management of patients with tinnitus using modern modes of communication and a multidisciplinary therapeutic approach. Implications for Practice Tinnitus can adversely affect quality of life while being time-consuming and costly to evaluate and manage. Based on both personal experience and the reports of others, patients with tinnitus who choose to see a physician primarily want to know two things: (1) that the tinnitus that is so distressing will not remain at the same level of severity forever and (2) that something can be done to help cope with the tinnitus that is so annoying. Recent advancements in internet communications, social media, information technology, artificial intelligence, machine learning, holistic medical care, mind-body integrative health care, and multidisciplinary approaches in medical therapeutics may be possibly making new ways of meeting the needs of patients with tinnitus.

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“…Antibiotics (aminoglycosides, tetracycline, macrolides, quinolones, vancomycin, metronidazole) 159–164 …”

Section: Discussionmentioning

confidence: 99%

Evaluation and Management of Tinnitus: Are There Opportunities for Improvement?

Grundfast

Jamil

2022

Otolaryngol.--head neck surg.

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“…Neurological adverse effects of metronidazole use include peripheral neuropathy, seizures, ototoxicity and encephalopathy 14 15. The clinical features of MIE commonly include altered mentation, cerebellar dysfunction and seizures 16.…”

Section: Discussionmentioning

confidence: 99%

Metronidazole-induced encephalopathy after prolonged metronidazole course for treatment ofC. difficilecolitis

et al. 2015

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A 65-year-old woman with a diagnosis ofClostridium difficilecolitis undergoing prolonged treatment with metronidazole was admitted to hospital for altered mentation, slurred speech and weakness. She was diagnosed with metronidazole-induced encephalopathy, confirmed with brain MRI and improved when the offending agent was removed. This case report highlights encephalopathy as a complication of prolonged metronidazole treatment, which has become more common in clinical practice for the treatment ofC. difficileinfection.

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“…There are only three metronidazole-associated SSNHL reports in the literature [6]. Metronidazole is a 5-nitromidazole antibiotic which is widely used against anaerobic bacteria and protozoal infections.…”

Section: Discussionmentioning

confidence: 99%

Sudden hearing loss subsequent to diarrhea: what is the missing link?

2014

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Sudden sensorineural hearing loss (SSNHL) is a debilitating condition with an incidence of nearly 20 per 100,000 in populations. Metronidazole-induced ototoxicity is an extremely rare etiology of SSNHL. In this report, we describe a young female with bilateral SSNHL due to oral use of metronidazole. A 23 years old female presented to the emergency department with acute bilateral hearing loss. We found out that her hearing loss had started 4 days after initiation of metronidazole which was administered for treatment of diarrhea. This case report shows that physicians should be aware of the uncommon side effects while prescribing metronidazole to patients in order to manage the possible adverse events on time.

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Metronidazole ototoxicity - report of two cases

Cited by 17 publications

References 1 publication

Evaluation and Management of Tinnitus: Are There Opportunities for Improvement?

Evaluation and Management of Tinnitus: Are There Opportunities for Improvement?

Metronidazole-induced encephalopathy after prolonged metronidazole course for treatment ofC. difficilecolitis

Sudden hearing loss subsequent to diarrhea: what is the missing link?

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