The safety of chemical processes is of critical importance. However, traditional fault monitoring methods have insufficiently studied the monitoring accuracy of multi-channel data and have not adequately considered the impact of noise on industrial processes. To address this issue, this paper proposes a neural network-based model, DSCBAM-DenseNet, which integrates depthwise separable convolution and attention modules to fuse multi-channel data features and enhance the model’s noise resistance. We simulated a real environment by adding Gaussian noise with different signal-to-noise ratios to the Tennessee Eastman process dataset and trained the model using multi-channel data. The experimental results show that this model outperforms traditional models in both fault diagnosis accuracy and noise resistance. Further research on a compressor unit engineering instance validated the superiority of the model.