Urban rail transit operations have changed from a single line to a multiline network. The network operations have undergone quantitative and qualitative changes, and operations management is facing rapid internal and external changes. Using the Guangzhou Metro network operation practices as a case study, this paper first systematically analyzes the features of the operation scale, the proportion of urban mass transit, the surge in public demand, the security of the operational service capacity, reforms to the operation governance structure, the highspeed expansion of staff, and the development of knowledge and skills in urban mass transit networks. The paper then proposes several responses to the challenges that such networks face; for example, this paper proposes creating an innovative network operations management system, strengthening the management foundation, creating plans to promote operation capacity, enhancing security risk management and equipment quality management, developing a crisis public relations response, and applying information technology. In addition, this paper systematically describes countermeasures for multiline network operations, such as developing a management mechanism for network operations, actively cultivating staff skills, creating innovative transport organization models to enhance operational capacity, establishing a production service assessment system to continuously improve the level of transportation service, establishing a quantifiable safety assessment system and equipment quality index model, strengthening quality controls for security and equipment, extensively using information technology to ensure the health of the urban mass transit network operation, and implementing sustainable development measures.