Methylxanthines Modulate Circadian Period Length Independently of the Action of Phosphodiesterase

Olivares-Yañez, Consuelo; Alessandrı̀, Maria Grazia; Salas, Loreto; Larrondo, Luis F.

doi:10.1128/spectrum.03727-22

Microbiol Spectr

2023

DOI: 10.1128/spectrum.03727-22

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Methylxanthines Modulate Circadian Period Length Independently of the Action of Phosphodiesterase

Consuelo Olivares-Yañez

Maria Grazia Alessandrı̀

Loreto Salas

et al.

Abstract: Evidence from diverse organisms show that caffeine causes changes in the circadian clock, causing period lengthening. The fungus Neurospora crassa is no exception; here, several methylxanthines such as caffeine, theophylline, and aminophylline cause period lengthening in a concentration-dependent manner.

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Sweetened caffeine drinking revealed behavioral rhythm independent of the central circadian clock in male mice

Tahara,

Ding,

Ito

et al. 2024

npj Sci Food

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Caffeine consumption is associated with the evening chronotype, and caffeine administration in mice results in prolonged period of the circadian rhythm in locomotor activity. However, as caffeine is bitter, sweetened caffeine is preferred by humans and mice; yet, its impact on the circadian clock has not been explored. In this study, mice were provided with freely available sweetened caffeine to investigate its effects on behavioral rhythms and peripheral clocks. Mice that freely consumed sweetened caffeine shifted from nocturnal to diurnal activity rhythms. In addition to the light-dark entrained behavioral rhythm component, some animals exhibited free-running period longer than 24-h. Intraperitoneal administration of caffeine at the beginning of the light phase also acutely induced diurnal behavior. The behavioral rhythms with long period (26–30 h) due to sweetened caffeine were observed even in mice housed under constant light or with a lesioned central circadian clock located in the suprachiasmatic nucleus of the hypothalamus; however, the rhythmicity was unstable. PER2::LUCIFERASE rhythms in peripheral tissues, such as the kidney, as measured via in vivo whole-body imaging during caffeine consumption, showed reduced amplitude and desynchronized phases among individuals. These results indicate that consumption of sweetened caffeine induces diurnal and long-period behavioral rhythms irrespective of the central clock, causing desynchronization of the clock in the body.

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Sweetened caffeine drinking revealed behavioral rhythm independent of the central circadian clock in male mice

Tahara,

Ding,

Ito

et al. 2024

npj Sci Food

View full text Add to dashboard Cite

show abstract

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Methylxanthines Modulate Circadian Period Length Independently of the Action of Phosphodiesterase

Cited by 1 publication

References 55 publications

Sweetened caffeine drinking revealed behavioral rhythm independent of the central circadian clock in male mice

Sweetened caffeine drinking revealed behavioral rhythm independent of the central circadian clock in male mice

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