Methylthioadenosine Suppresses Salmonella Virulence

Bourgeois, Jeffrey S.; Zhou, Daoguo; Thurston, Teresa L. M.; Gilchrist, James J.; Ko, Dennis C.

doi:10.1128/iai.00429-18

Cited by 15 publications

(23 citation statements)

References 79 publications

(89 reference statements)

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“…As a consequence of its pervasive presence, MTA regulates, directly or indirectly, expression, activity or both, of enzymes involved in methionine, AdoMet or polyamine biosynthesis (Anashkin et al, 2017). Being similar to AdoMet, but smaller, MTA often interferes with AdoMet synthesis or other processes (see for example Pang et al, 2017), with a variety of consequences on methionine availability, including inhibition of virulence of pathogens and production of antibiotics (Tojo et al, 2014;Wang et al, 2017;Bourgeois et al, 2018). The outcome of this constraint is that the level of the molecule is generally kept low in cells.…”

Section: Blue Arrows)mentioning

confidence: 99%

Revisiting the methionine salvage pathway and its paralogues

Sekowska

Ashida

Danchin

2018

Microbial Biotechnology

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SummaryMethionine is essential for life. Its chemistry makes it fragile in the presence of oxygen. Aerobic living organisms have selected a salvage pathway (the MSP) that uses dioxygen to regenerate methionine, associated to a ratchet‐like step that prevents methionine back degradation. Here, we describe the variation on this theme, developed across the tree of life. Oxygen appeared long after life had developed on Earth. The canonical MSP evolved from ancestors that used both predecessors of ribulose bisphosphate carboxylase oxygenase (RuBisCO) and methanethiol in intermediate steps. We document how these likely promiscuous pathways were also used to metabolize the omnipresent by‐products of S‐adenosylmethionine radical enzymes as well as the aromatic and isoprene skeleton of quinone electron acceptors.

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Section: Blue Arrows)mentioning

confidence: 99%

Revisiting the methionine salvage pathway and its paralogues

Sekowska

Ashida

Danchin

2018

Microbial Biotechnology

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“…It is well established that B cells are targets of Salmonella infection . In murine models, we observed that Salmonella Typhimurium is able to infect and survive within spleen B cells for up to 60 d postinfection .…”

Section: Bacteria Capable Of Infecting B Cellsmentioning

confidence: 79%

“…It is well established that B cells are targets of Salmonella infection. [22][23][24][25][26][27][28] In murine models, we observed that Salmonella…”

Section: Spi-5 Encodes a Series Of Proteins Responsible For Enteropatmentioning

confidence: 99%

Beyond the antibody: B cells as a target for bacterial infection

García-Gil

Lopez-Bailon

Ortiz-Navarrete

2019

Journal of Leukocyte Biology

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It is well established that B cells play an important role during infections beyond antibody production. B cells produce cytokines and are APCs for T cells. Recently, it has become clear that several pathogenic bacterial genera, such as Salmonella, Brucella, Mycobacterium, Listeria, Francisella, Moraxella, and Helicobacter, have evolved mechanisms such as micropinocytosis induction, inflammasome down‐regulation, inhibitory molecule expression, apoptosis induction, and anti‐inflammatory cytokine secretion to manipulate B cell functions influencing immune responses. In this review, we summarize our current understanding of B cells as targets of bacterial infection and the mechanisms by which B cells become a niche for bacterial survival and replication away from extracellular immune responses such as complement and antibodies.

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“…Nevertheless, experimental evidence has demonstrated that it is possible to inhibit MTA/SAH nucleosidase activity without severely affecting bacterial growth and without inducing resistance toward inhibitors (Gutierrez et al, 2009). In addition, Bourgeois et al (2018) observed that a Salmonella enterica serovar Typhimurium Δ metJ mutant strain, which was defective in methionine metabolism, presented elevated intracellular MTA levels without affecting bacterial growth (Bourgeois et al, 2018). In a S. aureus pfs mutant strain ( pfs encodes the MTA/SAH nucleosidase), growth was not impaired in nutrient-rich conditions but it was affected in zebrafish embryos (Bao et al, 2013).…”

Section: Methylthioadenosine/s-adenosylhomocysteine Nucleosidase Inhimentioning

confidence: 99%

Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens

Martínez

Rigueiras

Pires

et al. 2019

Front. Cell. Infect. Microbiol.

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Faced with the global health threat of increasing resistance to antibiotics, researchers are exploring interventions that target bacterial virulence factors. Quorum sensing is a particularly attractive target because several bacterial virulence factors are controlled by this mechanism. Furthermore, attacking the quorum-sensing signaling network is less likely to select for resistant strains than using conventional antibiotics. Strategies that focus on the inhibition of quorum-sensing signal production are especially attractive because the enzymes involved are expressed in bacterial cells but are not present in their mammalian counterparts. We review here various approaches that are being taken to interfere with quorum-sensing signal production via the inhibition of autoinducer-2 synthesis, PQS synthesis, peptide autoinducer synthesis, and N-acyl-homoserine lactone synthesis. We expect these approaches will lead to the discovery of new quorum-sensing inhibitors that can help to stem the tide of antibiotic resistance.

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Methylthioadenosine Suppresses Salmonella Virulence

Cited by 15 publications

References 79 publications

Revisiting the methionine salvage pathway and its paralogues

Revisiting the methionine salvage pathway and its paralogues

Beyond the antibody: B cells as a target for bacterial infection

Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens

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