Methylsulfonylmethane for treatment of low back pain: A safety analysis of a randomized, controlled trial

Crawford, Paul; Crawford, Amanda J.; Nielson, Frederick; Lystrup, Robert

doi:10.1016/j.ctim.2019.05.022

Cited by 8 publications

(4 citation statements)

References 11 publications

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“…Therefore, consideration of the formulation and administration methods of MSM is important to optimize its solubility and subsequent absorption. Its reported adverse effects, including gastrointestinal discomfort, bloating, and headache, are typically mild ( Liu et al, 2018 ; Crawford et al, 2019 ). However, the limited long-term safety data on MSM necessitates further research to facilitate its long-term use.…”

Section: Discussionmentioning

confidence: 99%

Methylsulfonylmethane ameliorates metabolic-associated fatty liver disease by restoring autophagy flux via AMPK/mTOR/ULK1 signaling pathway

Han,

Kim,

Kim

et al. 2023

Front. Pharmacol.

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Introduction: Metabolism-associated fatty liver disease (MAFLD) is a global health concern because of its association with obesity, insulin resistance, and other metabolic abnormalities. Methylsulfonylmethane (MSM), an organic sulfur compound found in various plants and animals, exerts antioxidant and anti-inflammatory effects. Here, we aimed to assess the anti-obesity activity and autophagy-related mechanisms of Methylsulfonylmethane.Method: Human hepatoma (HepG2) cells treated with palmitic acid (PA) were used to examine the effects of MSM on autophagic clearance. To evaluate the anti-obesity effect of MSM, male C57/BL6 mice were fed a high-fat diet (HFD; 60% calories) and administered an oral dose of MSM (200 or 400 mg/kg/day). Moreover, we investigated the AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin complex 1 (mTORC1)/UNC-51-like autophagy-activating kinase 1 (ULK1) signaling pathway to further determine the underlying action mechanism of MSM.Results: Methylsulfonylmethane treatment significantly mitigated PA-induced protein aggregation in human hepatoma HepG2 cells. Additionally, Methylsulfonylmethane treatment reversed the PA-induced impairment of autophagic flux. Methylsulfonylmethane also enhanced the insulin sensitivity and significantly suppressed the HFD-induced obesity and hepatic steatosis in mice. Western blotting revealed that Methylsulfonylmethane improved ubiquitinated protein clearance in HFD-induced fatty liver. Remarkably, Methylsulfonylmethane promoted the activation of AMPK and ULK1 and inhibited mTOR activity.Conclusion: Our study suggests that MSM ameliorates hepatic steatosis by enhancing the autophagic flux via an AMPK/mTOR/ULK1-dependent signaling pathway. These findings highlight the therapeutic potential of MSM for obesity-related MAFLD treatment.

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Section: Discussionmentioning

confidence: 99%

Methylsulfonylmethane ameliorates metabolic-associated fatty liver disease by restoring autophagy flux via AMPK/mTOR/ULK1 signaling pathway

Han,

Kim,

Kim

et al. 2023

Front. Pharmacol.

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“…Generally, clinical trial results suggest that CS, GCS, and MSM are safe substances when taken at typical doses as monotherapy, and do not exhibit significant adverse effects [7,37,38]. However, there have been reports of an interaction case where the coadministration of CS and GCS with warfarin resulted in an elevated INR [39].…”

Section: Discussionmentioning

confidence: 99%

Investigation of Drug-Interaction Potential for Arthritis Dietary Supplements: Chondroitin Sulfate, Glucosamine, and Methylsulfonylmethane

Kim,

Jo,

Park

et al. 2023

Molecules

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Osteoarthritis is one of the leading conditions that promote the consumption of these dietary supplements. Chondroitin sulfate, glucosamine, and methylsulfonylmethane are among the prominent alternative treatments for osteoarthritis. In this study, these dietary supplements were incubated with cytochrome P450 isozyme-specific substrates in human liver microsomes, and the formation of marker metabolites was measured to investigate their inhibitory potential on cytochrome P450 enzyme activities. The results revealed no significant inhibitory effects on seven CYPs, consistent with established related research data. Therefore, these substances are anticipated to have a low potential for cytochrome P450-mediated drug interactions with osteoarthritis medications that are likely to be co-administered. However, given the previous reports of interaction cases involving glucosamine, caution is advised regarding dietary supplement–drug interactions.

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“…Methyl sulfone (MSM), also known as dimethyl sulfone and methylsulfonylmethane, is an important organic sulfide that plays a key role in collagen synthesis and has potential health benefits, including increasing insulin sensitivity and promoting sugar metabolism in the body. , Because the treatment value and health function were explored continuously, high-purity MSM has predictable economic and social benefits. , However, the traditional nitrate oxidation method for MSM production has drawbacks such as high waste acid production, unpleasant odor of the MSM product, and safety concerns . With the advocacy of the concept of green chemicals, hydrogen peroxide (H 2 O 2 ) was employed as an oxidant to prepare MSM by oxidation of dimethyl sulfoxide (DMSO).…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Because the treatment value and health function were explored continuously, high-purity MSM has predictable economic and social benefits. 3,4 However, the traditional nitrate oxidation method for MSM production has drawbacks such as high waste acid production, unpleasant odor of the MSM product, and safety concerns. 5 With the advocacy of the concept of green chemicals, hydrogen peroxide (H 2 O 2 ) was employed as an oxidant to prepare MSM by oxidation of dimethyl sulfoxide (DMSO).…”

Section: Introductionmentioning

confidence: 99%

Continuous-Flow Synthesis of Methyl Sulfone with Microchannel Reactors: A Safer and Efficient Production Strategy

Chen

Liu

et al. 2023

Org. Process Res. Dev.

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The traditional batch production process for methyl sulfone (MSM) from dimethyl sulfoxide (DMSO) is highly exothermic and poses serious safety risks. In this work, we present a continuous-flow synthesis strategy using microchannel reactors to enhance the safety and efficiency of industrial-scale MSM production. Four specifications of microchannel reactors have been constructed and then were applied for the continuous-flow synthesis of MSM with both high yield and purity. The effects of the channel diameter, water bath temperature, catalytic dosage, residence time, and segmented temperature control on MSM yield were systematically investigated. By gradually optimizing the design parameters, the yield of MSM in the industrialized microchannel reactor reached 95.3%, and the average annual time yield of MSM was 18.36 t•a −1 . In addition, the maximum overlimit temperature in the continuous flow does not exceed 10 °C, and the overtemperature time is less than 20 s. Dual temperature-controlled continuous-flow process was more beneficial to increase the yield of MSM. The microchannel continuous-flow amplification process can greatly improve the productivity of MSM while ensuring the high yield of MSM, which is a promising strategy for the efficient and safe production of MSM at an industrial scale.

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Methylsulfonylmethane for treatment of low back pain: A safety analysis of a randomized, controlled trial

Cited by 8 publications

References 11 publications

Methylsulfonylmethane ameliorates metabolic-associated fatty liver disease by restoring autophagy flux via AMPK/mTOR/ULK1 signaling pathway

Methylsulfonylmethane ameliorates metabolic-associated fatty liver disease by restoring autophagy flux via AMPK/mTOR/ULK1 signaling pathway

Investigation of Drug-Interaction Potential for Arthritis Dietary Supplements: Chondroitin Sulfate, Glucosamine, and Methylsulfonylmethane

Continuous-Flow Synthesis of Methyl Sulfone with Microchannel Reactors: A Safer and Efficient Production Strategy

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