Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents

Lad, Nitin P.; Manohar, Yogesh; Mascarenhas, Malcolm; Pandit, Yashwant Bhaskar; Kulkarni, Mahesh R.; Sharma, Rajiv; Salkar, Kavita; Suthar, Amitabh B.; Pandit, S. S.

doi:10.1016/j.bmcl.2016.08.032

Cited by 37 publications

(20 citation statements)

References 19 publications

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“…This moiety can be functionalized with several structural modifications. Novel methylsulfonyl benzothiazoles were synthetized and evaluated against HeLA cell line, with compounds 6 and 7 (Figure 4) showing GI 50 values of 0.1 μM or below [22].…”

Section: Fused Thiazole Rings Decorated With Different Fragmentsmentioning

confidence: 99%

Thiazole Moiety: An Interesting Scaffold for Developing New Antitumoral Compounds

Ramos-Inza¹,

Aydillo²,

Sanmartín³

et al. 2020

Heterocycles - Synthesis and Biological Activities

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Currently, cancer is one of the major health problems of the human population and prominent cause of death. Thiazole ring has demonstrated many pharmacological activities including anticancer. This scaffold has been found alone or incorporated into the diversity of therapeutic active agents such as tiazofurin, dasatinib, and bleomycin, which are well-known antineoplastic drugs. Recently, most of the compounds isolated from natural sources containing thiazole moiety exhibit notable cytotoxicities and present antitumor potential. In this context, several structural changes have been made in the original structure, such as the incorporation of different substituents or the fusion with other carbo-and heterocycles, in order to increase the antitumoral potency. Related to mechanism of action of these derivatives, some of them act through kinase modulation, polymerization inhibition of microtubule, pro-matrix metalloproteinase activation, signal transducer activation of transcription 3, histone deacetylase inhibition, etc.

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Section: Fused Thiazole Rings Decorated With Different Fragmentsmentioning

confidence: 99%

Thiazole Moiety: An Interesting Scaffold for Developing New Antitumoral Compounds

Ramos-Inza¹,

Aydillo²,

Sanmartín³

et al. 2020

Heterocycles - Synthesis and Biological Activities

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“…A series of novel 4‐ and 5‐substituted methylsulfonyl benzothiazole derivatives were synthesized by Lad et al The synthesized compounds were screened for anticancer activity in cervical cancer (HeLa cell lines). Among the tested compounds, 3a and 3b showed significantly reduced cell growth with GI 50 values ≤0.1 µM.…”

Section: Biological Applications Of Benzothiazole Derivativesmentioning

confidence: 99%

“…A series of novel 4‐ and 5‐substituted methylsulfonylbenzothiazole derivatives were synthesized by Lad et al All the synthesized compounds were screened for antimicrobial activity. Results revealed that compounds 27a–f showed promising antimicrobial activity at MIC range of 4–50 µg/mL against selected bacterial as well as fungal species.…”

Section: Biological Applications Of Benzothiazole Derivativesmentioning

confidence: 99%

Therapeutic advancement of benzothiazole derivatives in the last decennial period

Tariq

Kamboj

Amir

2018

Arch. Pharm. Chem. Life Sci.

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Benzothiazole, a fused heterocyclic moiety, has attracted synthetic and medicinal chemists for good reasons. It is a valuable scaffold that possesses diverse biological activities, such as anticancer, anti-inflammatory, antimicrobial, antiviral, antimalarial, and anticonvulsant effects. This review mainly focusses on the recent research work on the different biological activities of benzothiazole-based compounds.

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“…Moreover, benzothiazoles attracted much interest in the last decades because of their diverse pharmaceutical applications. Many of their derivatives demonstrated a wide spectrum of biological activities such as antituberculosis, antimalarial, antifungal, anticancer, antiviral, anti‐inflammatory, antidiabetic, antioxidant, antiasthmatic, immunomodulatory properties, antibacterial, anthelmintic, and antileishmanial . Some selected drugs containing benzimidazole or benzothiazole moieties with diverse pharmaceutical properties are illustrated in Figure .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel bis‐ and poly(benzimidazoles) as well as bis‐ and poly(benzothiazoles) as anticancer agents

Hebishy

Abdelfattah

Elmorsy

et al. 2020

Journal of Heterocyclic Chem

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A synthesis of bis-and poly(benzimidazoles) as well as bis-and poly(benzothiazoles) was attempted using different protocols. The best results were obtained by employing the reaction of the appropriate bis-or poly(aldehydes) with o-phenylenediamine or 2-aminothiophenol, respectively, in ethanol at reflux in the presence of NaHSO 3 . The anticancer activities of the synthesized compounds were evaluated against human breast adenocarcinoma cell line (MCF-7), liver cancer cell line (HepG-2), and epithelial colorectal adenocarcinoma cells (CaCO-2). Hexakis(benzothiazole) was found to exhibit the highest activity against HepG-2 and MCF-7 cell lines with IC 50 values of 21.16 and 13.25 μM, respectively.

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Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents

Cited by 37 publications

References 19 publications

Thiazole Moiety: An Interesting Scaffold for Developing New Antitumoral Compounds

Thiazole Moiety: An Interesting Scaffold for Developing New Antitumoral Compounds

Therapeutic advancement of benzothiazole derivatives in the last decennial period

Synthesis of novel bis‐ and poly(benzimidazoles) as well as bis‐ and poly(benzothiazoles) as anticancer agents

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