Methylsiloxanes in plasma from potentially exposed populations and an assessment of the associated inhalation exposure risk

Guo, Junyu; Zhou, Ying; Sun, Mei; Cui, Jia’nan; Zhang, Boya; Zhang, Jianbo

doi:10.1016/j.envint.2020.105931

Cited by 15 publications

(8 citation statements)

References 38 publications

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“…VMS are commonly used in various cosmetics, household products, , and industrial products . Due to the health effects, VMS have been studied intensively. , VMS were found in the plasma of residents, , and hydrolyzed products of methylsiloxanes were detected in the human metabolites . Exposure to VMS can cause liver, endometrial, and respiratory damage, endocrine disturbances, and adverse immune responses. − However, the long-term toxicity and bioaccumulation of methylsiloxanes are still unclear and need further investigation. , …”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, methylsiloxanes in aerosols have not received much attention to date, and only a few studies have reported methylsiloxanes in indoor aerosols. ,− Most studies hypothesize that the methylsiloxanes in the particle phase are mainly derived directly or indirectly from the gas phase. In short, VMS can be oxidized into low-volatile products, which then condense on particles .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Methylsiloxanes from Vehicle Emissions Detected in Aerosol Particles

Yao,

Holzinger,

Materić

et al. 2023

Environ. Sci. Technol.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Methylsiloxanes from Vehicle Emissions Detected in Aerosol Particles

Yao,

Holzinger,

Materić

et al. 2023

Environ. Sci. Technol.

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“…Due to their mass manufacture and extensive applications, MSs have been detected in various environmental matrices, including air [ 10 , 11 , 12 , 13 ], water [ 14 , 15 , 16 , 17 ], soil [ 18 , 19 ], sediment [ 15 , 20 , 21 ], and biota [ 22 , 23 , 24 , 25 ]. Canada and the UK have assessed the environmental risk for CMSs (D4–D6), and the results showed that MSs could have potential adverse effects on the environment [ 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Occurrence and Behavior of Methylsiloxanes in Urban Environment in Four Cities of China

Yao

Guo

Zhou

et al. 2022

IJERPH

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Methylsiloxanes (MSs), used in industrial production and personal care products, are released in various environmental media. In this study, we combined monitoring and modeling to investigate the occurrence and behavior of MSs in the urban environment in China. MSs were widely found in the air, water, soil and sediment of four cities in China. The concentrations of MSs in all four environmental media of Zhangjiagang were higher than those in the other three cities (Beijing, Kunming and Lijiang), indicating that the siloxane production plant had a significant impact on the pollution level of MSs in the surrounding environment. The samples with high MS concentrations were all from the sample sites near the outlet of the WWTPs, which showed that the effluent of the WWTPs was the main source of MS pollution in the surrounding environment. The modeling results of the EQC level III model showed that D4 discharged into the environment was mainly distributed in the air, while D5 and D6 were mainly distributed in the sediment. CMSs (D4–D6) discharged into various environmental media could exist in the urban environment for a long time with low temperatures in cities. When the temperature was 0 °C, the residence time of D5 and D6 could be 68.1 days and 243 days in the whole environmental system in Beijing. This study illustrates the importance of CMSs (D4–D6) in low-temperature environments and the potential environmental risks that they may pose.

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“…Unfortunately, any application of pesticides brings with it concerns about the health of any workers who are exposed to the chemicals. Impacts include asthma, 10,11 cancer, 12 reproductive disorders, respiratory symptoms, 13 neurological symptoms, and skin irritations 14 via pathways such as ingestion, inhalation and skin contact 15–22 …”

Section: Introductionmentioning

confidence: 99%

“…Impacts include asthma, 10,11 cancer, 12 reproductive disorders, respiratory symptoms, 13 neurological symptoms, and skin irritations 14 via pathways such as ingestion, inhalation and skin contact. [15][16][17][18][19][20][21][22] Although seed-coating minimizes operating worker exposure to pesticides by treating seeds in coating machines and sealing pesticides with sowing seeds, there remains concern of an occupational exposure risk. Knowing to whom and where a high risk of exposure occurs will help improve safety during manufacturing.…”

Section: Introductionmentioning

confidence: 99%

Tracking pesticide exposure to operating workers for risk assessment in seed coating with tebuconazole and carbofuran

Han

Huang

et al. 2021

Pest Management Science

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BACKGROUND Coating seed with pesticides is an effective way to control plant pests, however, factory‐based coating processes may carry a potential risk to operational workers of chemical exposure. To study the risk, carbofuran and tebuconazole were used to coat corn seed and their subsequent distribution on the bodies of workers was measured at manufacturers XFS and LS (Shanxi, China). Clothing was collected from workers during operations and analyzed using high‐performance liquid chromatography. RESULTS At XFS, dermal exposure to carbofuran was 4.83, 3.31 and 1.48 mg kg−1, and exposure to tebuconazole was 6.88, 5.16 and 1.72 mg kg−1 for coating, packing and transport workers, respectively. At LS, dermal exposure to carbofuran was 2.32, 0.46 and 0.55 mg kg−1, and exposure to tebuconazole was 1.69, 0.46 and 0.70 mg kg−1, for coating, packing and transport workers, respectively. The level of pesticide exposure was significantly higher for seed‐coating workers than for packing and transport workers. The main area of exposure was the hands for all workers and the lower limbs for packers; exposure was relatively uniform for pesticide handlers. Occupational risk was assessed based on margin of exposure (MOE). In seed‐coating, the MOE was greater than 100 for tebuconazole, indicating no potential risk, but ranged from 0.25 to 2.88 for carbofuran, indicating the risk of a health impact. CONCLUSION The level of exposure varied depending on type of operation undertaken and body parts of workers' body, but the risk of a health impact was highly associated with pesticide toxicity. This provides a guideline for workers in pesticide manufacturing to ensure safe operation of the seed‐coating process. © 2021 Society of Chemical Industry

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Methylsiloxanes in plasma from potentially exposed populations and an assessment of the associated inhalation exposure risk

Cited by 15 publications

References 38 publications

Methylsiloxanes from Vehicle Emissions Detected in Aerosol Particles

Methylsiloxanes from Vehicle Emissions Detected in Aerosol Particles

Occurrence and Behavior of Methylsiloxanes in Urban Environment in Four Cities of China

Tracking pesticide exposure to operating workers for risk assessment in seed coating with tebuconazole and carbofuran

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