Methylprednisolone, Valacyclovir, or the Combination for Vestibular Neuritis

Strupp, Michael; Zingler, V. C.; Arbusow, Viktor; Niklas, Daniel; Maag, Klaus; Dieterich, Marianne; Bense, Sandra; Theil, Diethilde; Jahn, Klaus; Brandt, Thomas

doi:10.1056/nejmoa033280

Cited by 396 publications

(251 citation statements)

References 26 publications

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“…This study confirms prior reports showing peripheral vestibular function improvement in patients with AUV receiving glucocorticoids on admission [3,20,21]. Additionally, we have shown that the improvement in canal paresis with glucocorticoid treatment correlates with a reduction in the degree of nystagmus.…”

Section: Discussionsupporting

confidence: 92%

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Glucocorticoids improve acute dizziness symptoms following acute unilateral vestibulopathy

et al. 2015

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Section: Discussionsupporting

confidence: 92%

“…One study probed the effects of corticosteroids with and without antivirals and concluded that methylprednisolone, but not valacyclovir, improves the recovery of vestibular function in these patients [21]. Other studies have confirmed the effects of glucocorticoids on peripheral vestibular function following acute AUV [18,20].…”

Section: Introductionmentioning

confidence: 99%

Glucocorticoids improve acute dizziness symptoms following acute unilateral vestibulopathy

et al. 2015

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“…Such an analysis is particularly important in the light of recent suggestions that steroid treatment for acute VN improves peripheral-vestibular recovery (albeit measured with the caloric test and without symptom assessment) [1,16].…”

Section: Discussionmentioning

confidence: 99%

Vestibular neuritis: Vertigo and the high-acceleration vestibulo-ocular reflex

2008

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Acknowledgements:The authors thank Dr. S. Marti and Dr. K. Weber for performing some of the measurements as well as A. Züger, T. Schmückle, and E. Schafflützel for technical assistance. Disclosure:The authors have reported no conflicts of interest. -Palla et al. ABSTRACTPatients after vestibular neuritis (VN) often report persistent dizziness and disequilibrium. We correlated persistent symptoms with sustained impairment of the high-acceleration horizontal vestibulo-ocular reflex as determined by quantitative search-coil head-impulse testing (qHIT). In 47 patients, qHIT was recorded 0-60 months and symptoms assessed with the Yardley Vertigo Symptom Scale short form ≥18 months after VN onset. No correlation between the magnitude of highacceleration vestibular impairment and the severity of vertigo symptoms was observed. The lack of symptom-qHIT correlation suggests that defective compensation at more rostral level in the central nervous system may be responsible for protracted symptoms in VN patients.3 -Palla et al.

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“…89 However, the efficacy of corticosteroids is controversial. A recent Cochrane review concluded that there is currently insufficient evidence to support the use of corticosteroids in patients with idiopathic acute vestibular dysfunction.…”

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confidence: 99%