Methylprednisolone Use is Associated with Endothelial Cell Activation Following Cardiac Surgery

Ломиворотов, В. В.; Efremov, Sergey; Калиниченко, А. П.; Kornilov, Igor; Knazkova, Lubov G.; Cherniavsky, Alexander; Ломиворотов, В. Н.; Karaskov, Alexander

doi:10.1016/j.hlc.2012.08.001

Cited by 8 publications

(7 citation statements)

References 26 publications

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“…Four trials 8-11 reported levels of IL-10. Jale Bengi et al 8 (p<0.05) and Vladimir et al, 10 (p<0.05) showed that levels of IL-10 were significantly greater in the methylprednisolone group than in the placebo group, but Demir et al, 9 and Keski-Nisula et al, 11 showed that there was no statistically significant difference between the methylprednisolone group and the placebo group. According to the overall analysis, methylprednisolone can reduce TNF-α, IL-6, and IL-8 release.…”

Section: Resultsmentioning

confidence: 98%

“…The initial search identified 406 records, but this systematic review only included 6 trials [6][7][8][9][10][11] by the inclusion criteria and exclusion criteria as shown in Figure 1. Patient characteristics and Jadad scale were summarized in Table 1 the risk of bias as noted in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…The quality of the studies was various; the majority was poor quality studies, and there were only 2 high quality trials. 10,11 Two trials 7, 8 reported levels of TNF-α. Ayda et al 7 showed that levels of TNF-α (p<0.05) at 24 hours after CPB were significantly greater in the placebo group than in the methylprednisolone group.…”

Section: Resultsmentioning

confidence: 99%

“…Only one trial 7 reported levels of IL-1β at 24 hours after CPB, but there was no statistically significant difference between the methylprednisolone group and the placebo group. Six studies [6][7][8][9][10][11] reported levels of IL-6. Four trials [6][7][8][9] indicated that levels of IL-6 at 24 hours after CPB were significantly greater in the placebo group than in the methylprednisolone group.…”

Section: Resultsmentioning

confidence: 99%

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The Efficacy of Methylprednisolone Treatment in Inflammatory Response during Cardiopulmonary Bypass: A Systematic Review

Sun¹

2017

MOJT

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Search strategy and selection criteriaFour electronic databases were searched for articles published up to April 1, 2016 without language restriction, containing Pub Med, EMBASE, Cochrane Central and Web of Science. The search terms used are presented as follows: ['heart-lung bypass' OR 'bypass, heart-lung' OR 'bypasses, heart-lung' OR 'heart lung bypass' OR 'heart-lung bypasses' OR 'bypass, cardiopulmonary' OR 'bypasses, cardiopulmonary' OR 'cardiopulmonary bypasses'] AND ['metipred' OR '6-methylprednisolone' OR '6 methylprednisolone' OR 'urbason' OR 'medrol'] AND ['random' OR 'randomized controlled trial']. The reference lists of relevant reviews were also hand searched to identify additional studies. We included studies according to the following inclusion criteria:A. Participants undergoing cardiopulmonary bypass; B. Patients were randomized grouped into the methylprednisolone group (without other drug) and the placebo group (with or without placebo ); C. Not less than one outcome ((tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10)); D. Randomized controlled trials. The articles which were retrospective studies, observational studies, case series, reviews, comments, duplicate published articles, and studies without original data were also eliminated. Data extractionTwo authors independently collected on the following data: the first author, publication year, sample size, study design, patient characteristics, the methylprednisolone group (dosage, duration), the placebo group (dosage, duration), and measured outcome (tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10)).We made a detailed discussion when disagreements of this process occurred.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

The Efficacy of Methylprednisolone Treatment in Inflammatory Response during Cardiopulmonary Bypass: A Systematic Review

Sun¹

2017

MOJT

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“…Endothelial dysfunction is purported to be one of the primary causes of postoperative lung failure. 98 Depending on the outcome of the large-scale SIRS trial, prophylaxis with steroids in the form of dexamethasone to decrease the inflammatory response is not indicated.…”

Section: Separation From Bypassmentioning

confidence: 99%

Anesthetic Management for Cardiopulmonary Bypass

Bechtel

Huffmyer

2014

Semin Cardiothorac Vasc Anesth

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Cardiopulmonary bypass has revolutionized the practice of cardiac surgery and allows safe conduct of increasingly complex cardiac surgery. A brief review of the bypass circuit is undertaken in this review. A more thorough review of the anesthetic management is accomplished including choice of anesthetic medications and their effects. The inflammatory response to cardiopulmonary bypass is reviewed along with interventions that may help ameliorate the inflammation.

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Prophylactic corticosteroids for cardiopulmonary bypass in adult cardiac surgery

Abbasciano,

Olivieri,

Chubsey

et al. 2024

Cochrane Database of Systematic Reviews

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Methylprednisolone Use is Associated with Endothelial Cell Activation Following Cardiac Surgery

Cited by 8 publications

References 26 publications

The Efficacy of Methylprednisolone Treatment in Inflammatory Response during Cardiopulmonary Bypass: A Systematic Review

The Efficacy of Methylprednisolone Treatment in Inflammatory Response during Cardiopulmonary Bypass: A Systematic Review

Anesthetic Management for Cardiopulmonary Bypass

Prophylactic corticosteroids for cardiopulmonary bypass in adult cardiac surgery

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