Methylprednisolone Infusion in Early Severe ARDS

Meduri, G. Umberto; Golden, Emmel; Freire, Amado X.; Taylor, E. W.; Zaman, Mohd Saif; Carson, Stephanie; Gibson, Mary; Umberger, Reba

doi:10.1378/chest.06-2100

Cited by 659 publications

(315 citation statements)

References 43 publications

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“…Although HC, a pharmacologic form of physiological cortisol, is most commonly used in large‐scale RCTs, it is a short‐acting steroid and has both glucocorticoid and mineralocorticoid effects. In addition, Meduri et al 173. administered 1 mg/kg of MPSL, an intermediate‐acting steroid with no mineralocorticoid effects, and then continued MPSL administration at 1 mg/kg/day for 14 days to patients with septic shock in the same way as is given to patients with acute respiratory distress syndrome (ARDS).…”

Section: Cq8: Corticosteroid Therapy For Septic Shockmentioning

confidence: 99%

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

Nishida

Ogura

Egi

et al. 2018

Acute Medicine & Surgery

157

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Background and PurposeThe Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG 2016), a Japanese‐specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 in Japanese. An English‐language version of these guidelines was created based on the contents of the original Japanese‐language version.MethodsMembers of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ), and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two‐thirds (>66.6%) majority vote of each of the 19 committee members.ResultsA total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J‐SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation and its supporting evidence were also added to each recommendation statement. We conducted meta‐analyses for 29 CQs. Thirty seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for 5 CQs.ConclusionsBased on the evidence gathered, we were able to formulate Japanese‐specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non‐specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals.

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Section: Cq8: Corticosteroid Therapy For Septic Shockmentioning

confidence: 99%

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

Nishida

Ogura

Egi

et al. 2018

Acute Medicine & Surgery

157

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“…A randomized controlled trial in USA revealed that methyl prednisolone administration during early severe ARDS is associated with significant improvement in pulmonary and non-pulmonary organ dysfunction, which in turn reduces the duration of mechanical ventilation 8 .…”

Section: Discussionmentioning

confidence: 99%

Management of severe measles related pneumonia, acute respiratory distress syndrome and pleural effusion with intravenous methyl prednisolone, immunoglobulin and oral vitamin A

Liyanage

Faizal

Kanankearachchi

2016

Sri Lanka J Child Health

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“…The study was conducted with institutional approval and informed consent. Patient selection was done through the ICU data base [3]. The intensive care unit is a multipurpose unit with a capacity of 14 beds, each equipped with different levels of complexity in a hospital of third level of care [4,5].…”

Section: Methodsmentioning

confidence: 99%

Pulmonary Diffusion Capacity and Quality of Life during a Period of 6 Years in Patients who Survived Acute Respiratory Distress Syndrome

Le¹,

Laime²,

Fiore³

et al. 2017

Intern Med

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Methylprednisolone Infusion in Early Severe ARDS

Cited by 659 publications

References 43 publications

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

Management of severe measles related pneumonia, acute respiratory distress syndrome and pleural effusion with intravenous methyl prednisolone, immunoglobulin and oral vitamin A

Pulmonary Diffusion Capacity and Quality of Life during a Period of 6 Years in Patients who Survived Acute Respiratory Distress Syndrome

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