Methylprednisolone-Induced Toxic Hepatitis

Abstract

Although rare, hepatotoxicity related to methylprednisolone should be considered in patients who develop elevated enzyme levels while receiving this steroid.

Case Report: Mixed Cholestatic/Hepatocellular Liver Injury Induced by the Herbicide Quizalofop-p-ethyl

“…It is noteworthy that c-ANCA were undetected 2, 3, and 9 months after exposure, and serum β 2 -MG levels were normal 9 months after exposure (2.51 mg/L). Also, the second low peak in aminotransferase levels, determined in the 35th week (Figure 1), could be attributed either to a second late onset of QpE hepatotoxicity or to steroid treatment (Topal et al 2006). The patient was treated with UDCA, as reported by Watkins and Seeff (2006).…”

Hepatotoxicity Induced by High Dose of Methylprednisolone Therapy in a Patient with Multiple Sclerosis: A Case Report and Brief Review of Literature

“…The direct toxic hepatitis occurs with predictable regularity in patients that exposed to the agents and it is related to the dose dependent, while the idiosyncratic is unpredictable and it seem to be dose-independent; it usually occurs within days to months to start of injury [4] [5]. Sometimes patients may developed liver toxicity after the drugs was stopped even in months [6].…”

Bolus de méthylprednisolone révélant une hépatite auto-immune chez une patiente atteinte de sclérose en plaques

“…Contrairement à l'IFN-β, le plus souvent utilisée dans le traitement de la SEP et entraînant, dans environ 40 % des cas, des perturbations de la biologie hépatique, le plus souvent modérées, la toxicité hépatique induite par la MP est rare [7]. En effet, de rares cas d'hé-patite mixte à la fois cytolytique et cholestatique ont été décrits [8]. L'induction de l'HAI par ce traitement administré par voie IV à fortes doses serait due, selon Reuß et al, à un phénomène de rebond immunitaire dû à une immunosuppression engendrée par le traitement [4].…”