“…Positive cohort drugs were expected to have off-label drug usage, whereas the negative cohort drugs were not expected to have major off-label drug usage. After a review of the literature, the following drugs were selected as the positive cohort, as they were known to have off-label uses: pregabalin, 11 gabapentin, 11 , 12 lorazepam, 13 methylphenidate, 14 amitriptyline, 15 and quetiapine. 16 The negative cohort drugs considered were as follows: levonorgestrel, levofloxacin, clopidogrel, celecoxib, buprenorphine-naloxone, and natalizumab.…”