Methylphenidate Therapy for Aggression in a Man With Ring 22 Chromosome

Molecular characterisation of a ring chromosome 22 in a patient with severe language delay: a contribution to the refinement of the subtelomeric 22q deletion syndrome

“…[1][2][3][4][5][6][7][8][9] Second and third toe syndactyly, unsteady gait, hyperactivity, aggressive behaviour, autistic disorders, 3 4 and seizures or abnormal EEG 1 2 have also been reported. The recently described subtelomeric 22q deletion syndrome showed overlapping clinical features with a generalised developmental delay, particularly severe in the area of expressive speech.…”

Determination of the breakpoints and the parental origin of a ring 22 chromosome: An analysis by high-resolution banding technique, quinacrine and silver stainings

“…Since Hunter et aL (1977) reviewed clinical features of r(22) syndrome on 21 cases, additional 17 cases have, to our knowledge, been reported including the present case (Palmer et al, 1977;Howard-Peebles, 1977;Funderburk et al, 1979;Faed et al, 1979;Fryns et al, 1979;Aller et aI., 1979;Sakuragawa et al, 1979;Fowler et al, 1980;Kondo et al, 1980;Stoll and Roth, 1983;Reeve et al, 1985). As mentioned by Funderburk et al (1979), there is considerable variability in its expression from normal mentality to profound mental retardation with multiple minor anomalies.…”

Coexistence of Autism and Ring Chromosome 22

“…On the other hand, ocular, neurological and dermatological examinations are recommended every two years, as well as audiological examinations and cranial MRI for NF-II in patients with ring chromosome 22 (23). Autism symptoms, mood disorders, hyperactivity, aggressive behaviors and self-destructive behaviors have been reported in cases with ring chromosome 22 in the literature (16)(17)(18)24,25). In our literature review, the reason for scarcity of data related to comorbid psychiatric diseases in cases with ring chromosome 22 may be due to the fact that the majority of the published cases are in the childhood period and the long-term follow-up results of these cases have not been reported yet.…”