Methylphenidate (Ritalin®) treatment of cocaine dependence—A preliminary report

Khantzian, Edward J.; Gawin, Frank H.; Kleber, Herbert D.; Riordan, Charles E.

doi:10.1016/0740-5472(84)90033-3

Cited by 113 publications

(35 citation statements)

References 6 publications

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“…Dopaminergic Agents. Therapeutics such as methylphenidate and other medications (e.g., bromocriptine, pergolide, and amantadine), which act as dopamine agonists, also show limited efficacy in the treatment of cocaine addiction (Khantzian et al, 1984;Grabowski et al, 1997;Handelsman et al, 1997;Malcolm et al, 2000;Shoptaw et al, 2002). The efficacy of methylphenidate, however, may be apparent only in cocaine addicts with comorbid attention deficit/hyperactivity disorder rather than cocaine addicts in general (Gawin et al, 1985;Levin et al, 1998;Schubiner et al, 2002).…”

Section: Cocaine Addictionmentioning

confidence: 99%

Pharmacogenetics and Human Molecular Genetics of Opiate and Cocaine Addictions and Their Treatments

et al. 2005

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Section: Cocaine Addictionmentioning

confidence: 99%

Pharmacogenetics and Human Molecular Genetics of Opiate and Cocaine Addictions and Their Treatments

et al. 2005

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“…Depression has also been found to be associated with a variety of specific drugs. Cocaine dependent users suffered from emotional liability and restlessness, along with depression (Khantzian, Gawin, & Kleber, 1984;. In addition, narcotic and multiple drug users have been susceptible to depression according to several studies (Rounsaville, Weissman, & CritsCristoph, 1982;Woody, 03rien, & McLellen, 1979;Woody, O Brien, & Rickels, 1975).…”

Section: Psychological Correlates Of Drug Usementioning

confidence: 99%

Psychological Factors Related to Drug Use in College Athletes

Evans¹

1992

The Sport Psychologist

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figures, references, 69 titles.The purpose of the present investigation was to compare the psychological factors related to drug use by college athletes on seven drug categories. A questionnaire was given to male and female Division I college athletes asking them about their use of drugs. The frequency, intensity and duration of use/non-use was used to divide subjects into high and low/nonuser categories. Dependent measures included the Profile of Mood States, Coopersmith Self-Esteem Inventory and questions assessing athlete stress. A multivariate analysis of variance(MANOVA) was conducted in a 2 x 2 (alcohol high/low, non-user x male/female) design to distinguish significant differences on the POMS and stress questions followed by univariate ANOVA's. A separate ANOVA was run on Coopersmith's Self-Esteem Inventory. Results indicated that high alcohol users scored significantly higher on anger, fatigue and vigor than low/non-users. Significant differences were found between males and females on the pressure felt from coaches to perform well.

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“…ADHD is overrepresented in adults seeking treatment for cocaine and other drug dependence (e.g., Levin et al, 1998). It has been hypothesized that individuals with ADHD may use various substances, particularly cocaine, in an attempt to 'self-medicate' ADHD symptoms (e.g., Khantzian, 1983;Khantzian et al, 1984). In addition, evidence suggests that treatment of ADHD with stimulants such as MPH may decrease the risk of developing a substance use disorder in adolescents with ADHD (Wilens et al, 2003).…”

Section: Introductionmentioning

confidence: 99%