Methylphenidate Induced Psychotic Symptoms: Two Cases Report

Hesapcioglu,

doi:10.4021/jmc923w

Cited by 5 publications

(7 citation statements)

References 11 publications

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“…Short lasting and self-limited psychotic features after ingesting extra doses of stimulants can be experienced independently from current psychological state of people [8]. It is claimed that stimulants that are taken above the therapeutic doses cause visual stimulation that can be perceived diversely due to the mechanism of the increased norepinephrine in lateral geniculate nucleus resulting an accelerated visual information flow [3]. These experiences mostly subside following the cessation of the medication like in our patient [10].…”

Section: Discussionmentioning

confidence: 88%

“…Methylphenidate is the most commonly used agent and it is the first option in treatment. MPH acts via specifically blocking presynaptic norepinephrine and dopamine transporters, impedes their reuptake thereby increases their levels in synaptic cleft [2,3]. MPH is safely used in children, adolescents and adults due to its low adverse effect profile.…”

Section: Introductionmentioning

confidence: 99%

“…It is designated that this explicit mental state is short lasting, generally limits itself within a few hours and its possible ethiopathogenesis is chiefly related with increase in concentration of synaptic Hallusinosis due to methylphenidate overdose in an eight-year-old child: a case report Hallusinosis due to methylphenidate overdose Marmara Medical Journal 2016; 29: 177-180 dopamine [4]. This presentation could be observed even after the first or low dose methylphenidate ingestion and idiosyncratic mechanisms have been speculated [3]. If abrupt pyschosis symptoms are observed as adverse effects of stimulants used for ADHD treatment, then the cessation of stimulant treatment and switching to atomoxetine treatment is recommended [9].…”

Section: Introductionmentioning

confidence: 99%

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Hallusinosis due to methylphenidate overdose in an eight-year-old child: a case report

Atabay

Arman

2017

MMJ

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Methylphenidate, which blocks the presynaptic norepinephrine and dopamine transporters, is the most common used medication and offered as first choice in the treatment guidelines of attention deficit hyperactivity disorder (ADHD). One of its rarely seen adverse effects is, hallucinations that can be formed idiosyncratically, which can be correlated with increased dopaminergic functioning in synaptic cleft. We will present an eight year old boy diagnosed with ADHD-combined type, and oppositional defiant disorder (ODD) with no previous medical and family history who has impulsively taken extra dose of methylphenidate in the course of usual drug treatment. The acute hallucinosis presentation which has subsided the next day completely with the cessation of drug treatment will be discussed. Keywords:Methylphenidate, Hallucinosis, Attention deficit hyperactive disorder ÖZPresinaptik norepinefrin ve dopamin taşıyıcılarını bloke eden metilfenidat, dikkat eksikliği hiperaktivite bozukluğu (DEHB) tedavisinde en sık kullanılan ve tedavi rehberlerinde birinci tercih olarak sunulan ilaçtır. Nadir karşılaşılan yan etkilerinden biri de, sinaptik aralıktaki artmış dopaminerjik işleyiş ile ilişkilendirilen, idiosenkratik oluşabilen varsanılardır. Polikliniğimizde DEHBbileşik tip ve karşıt olma karşı gelme bozukluğu (KOKGB) teşhisi konularak metilfenidat tedavisine başladığımız, özgeçmiş ve soygeçmişinde herhangi bir hastalık öyküsü bulunmayan sekiz yaşındaki erkek bir çocukta, olağan ilaç tedavisi sırasında impulsif bir şekilde aldığı fazladan bir doz kısa etkili metilfenidat ile gelişen ve ilacın kesilmesiyle birlikte ertesi gün tümüyle gerileyen halüsinoz tablosunu tartışacağız.Anahtar kelimeler: Metilfenidat, Halüsinoz, Dikkat eksikliği hiperaktivite bozukluğu IntroductionAttention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorder in school age children. It is a heterogeneous disorder which is composed of core symptoms including hyperactivity, attention deficit and impulsivity. Short and long acting methylphenidate (MPH), amphetamine, mixed amphetamine salts, and atomoxetine are utilized for the pharmacologic treatment [1]. Methylphenidate is the most commonly used agent and it is the first option in treatment. MPH acts via specifically blocking presynaptic norepinephrine and dopamine transporters, impedes their reuptake thereby increases their levels in synaptic cleft [2,3]. MPH is safely used in children, adolescents and adults due to its low adverse effect profile. Among the most common adverse effects; sleeplessness, stomachache, headache, loss of appetite, irritability and anxiety can be considered. Relatively less commonly, tics and emotional fluctuations also can be seen [4]. In addition, in 1971 Lucas and Weiss, mentioned short lasting psychotic symptoms in patients who utilize methylphenidate [5]. In the current literature, "hallucinosis" and "toxicosis" terms are particularly used in order to differentiate temporary symptoms related to stimulants in contrast to perma...

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hallusinosis due to methylphenidate overdose in an eight-year-old child: a case report

Atabay

Arman

2017

MMJ

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“…About 1 in 400 patients treated with stimulants at a therapeutic dose will develop toxicosis with symptoms of psychosis or mania 11. Case reports in the literature suggest that such psychosis disappears within days to weeks after the amphetamines are discontinued 12 13. However, another case report suggests that antipsychotics may be effective even with concurrent use of psychostimulants 14…”

Section: Discussionmentioning

confidence: 99%

Acute psychosis with attention-deficit/hyperactivity disorder and oppositional-defiant disorder comorbidities

Ding

Gadit

2014

BMJ Case Reports

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This is a case of an 18-year-old boy who presented with his mother in the emergency room with a 1-week history of paranoia and bizarre behaviour. His comorbidities included attention-deficit/hyperactivity disorder, oppositional-defiant disorder and mild intellectual delay. At the emergency room he was incoherent, agitated and uncooperative. He was admitted to the psychiatric inpatient unit and treated with low-dose risperidone. The patient's symptoms improved markedly over a few days, although he remained restless and had episodes of agitation. Nursing staff was concerned about his behaviour and found him difficult to manage. However, after speaking to the patient's family, this was felt to be his baseline. After 11 days the patient was discharged home in stable state.

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“…Violence, agitation, and depression with suicidal ideation have also been reported in previous studies. [ 4 5 ]…”

Section: Introductionmentioning

confidence: 99%

Methylphenidate and suicidal ideation: Report of two cases

Arun

Sahni

2014

Indian J Psychiatry

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Stimulant prescriptions are routinely used to treat Attention Deficit Hyperactivity Disorder. Reports of psychiatric symptoms that have occurred include euphoria, delirium, confusion, toxic psychosis, and hallucinations. Here, authors report two cases of Attention Deficit Hyperactivity Disorder who were prescribed methylphenidate. Both children developed suicidal ideation that abated after discontinuing the drug. There were no depressive symptoms reported along with it, and the ideation could not be explained on the basis of impulsivity either.

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Methylphenidate Induced Psychotic Symptoms: Two Cases Report

Cited by 5 publications

References 11 publications

Hallusinosis due to methylphenidate overdose in an eight-year-old child: a case report

Hallusinosis due to methylphenidate overdose in an eight-year-old child: a case report

Acute psychosis with attention-deficit/hyperactivity disorder and oppositional-defiant disorder comorbidities

Methylphenidate and suicidal ideation: Report of two cases

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