1996
DOI: 10.1016/s0003-9993(96)90211-7
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Methylphenidate effect on attention deficit in the acutely brain-injured adult

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Cited by 104 publications
(64 citation statements)
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“…17 Overall, methylphenidate may accelerate the return to normal of hypofunctioning neurons or neural circuits. 12 The results of this study are largely consistent with previous research demonstrating methylphenidate-induced enhancement of consciousness in ABI. Although previous research suggesting the beneficial effect of methylphenidate in the early recovery phase after brain injury reported that this compound stimulated the formation of new synapses, 12 augmented neural activity within the reticular activating system, 8,18 and had a neuroprotective effect, 19 little is known about the anatomical target in the cerebral cortex associated with the recovery of consciousness after methylphenidate treatment in ABI.…”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…17 Overall, methylphenidate may accelerate the return to normal of hypofunctioning neurons or neural circuits. 12 The results of this study are largely consistent with previous research demonstrating methylphenidate-induced enhancement of consciousness in ABI. Although previous research suggesting the beneficial effect of methylphenidate in the early recovery phase after brain injury reported that this compound stimulated the formation of new synapses, 12 augmented neural activity within the reticular activating system, 8,18 and had a neuroprotective effect, 19 little is known about the anatomical target in the cerebral cortex associated with the recovery of consciousness after methylphenidate treatment in ABI.…”
Section: Discussionsupporting
confidence: 90%
“…7,8,12,13 However, no study has reported on changes in the metabolic pattern of cerebral cortex after methylphenidate therapy in patients with impaired consciousness after ABI. In this study, we evaluated the changes of cerebral metabolic pattern between before and after methylphenidate treatment and correlated cerebral glucose metabolism with improvement in the level of consciousness using SPM analysis.…”
Section: Discussionmentioning
confidence: 99%
“…Methylphenidate has been shown in several RCTs to improve attention after TBI [149]. These trials include a double-blind crossover trial in chronic TBI [154] and several additional RCTs of mild and moderate to severe TBI [155][156][157][158]. Case report and chart review data also support dextroamphetamine for improved attention after TBI [149].…”
Section: Managing Cognitive Complaintsmentioning
confidence: 98%
“…Baseline attention may predict response to methylphenidate treatment of apathy which may in turn improve attention (23). We chose to measure attention with Wechsler Memory Scale – Revised (WMS-R) digit span tests (56) which has been reported to effectively measure attention, concentration, sequencing, number facility and auditory short-term memory (5759) in dementia populations and to be a sensitive measure of drug response in methylphenidate trials (60). …”
Section: Issues In Designing a Trial To Test Treatments For Apathymentioning
confidence: 99%