Methylphenidate and Dyslipidemia

Charach, Gideon; Kaysar, Nechemia; Rabinovich, Alexander; Argov, Ori; Weintraub, Moshe

doi:10.5772/31140

Cited by 3 publications

(2 citation statements)

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“…It was shown that the levels of neurotransmitters and metabolites in Drosophila brain were dose dependent following administered MPH, and these were saturated at the administration dose of 20–25 mM . There is also evidence that in addition to acting on the catecholamine systems, MPH induces significant changes in the lipid composition of the brain, blood, and plasma . However, detailed information about specific kinds of lipids as well as spatial distributions of the target molecules affected by the drug has not been provided.…”

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Lipid Structural Effects of Oral Administration of Methylphenidate inDrosophilaBrain by Secondary Ion Mass Spectrometry Imaging

2015

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We use time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging to investigate the effects of orally administrated methylphenidate on lipids in the brain of Drosophila melanogaster (fruit fly), a major invertebrate model system in biological study and neuroscience. TOF-SIMS imaging was carried out using a recently designed high energy 40 keV Ar4000(+) gas cluster ion gun which demonstrated improved sensitivity for intact lipids in the fly brain compared to the 40 keV C60(+) primary ion gun. In addition, correlation of TOF-SIMS and SEM imaging on the same fly brain showed that there is specific localization that is related to biological functions of various biomolecules. Different lipids distribute in different parts of the brain, central brain, optical lobes, and proboscis, depending on the length of the carbon chain and saturation level of fatty acid (FA) branches. Furthermore, data analysis using image principal components analysis (PCA) showed that methylphenidate dramatically affected both the distribution and abundance of lipids and their derivatives, particularly fatty acids, diacylglycerides, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol in the fly brains. Our approach using TOF-SIMS imaging successfully visualizes the effects of methylphenidate on the chemical structure of the fly brain.

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Lipid Structural Effects of Oral Administration of Methylphenidate inDrosophilaBrain by Secondary Ion Mass Spectrometry Imaging

2015

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“…It increased by 22%, similar to previous studies. [ 8 , 15 ] Data on amphetamine-like substances and hyperglycemia are inconsistent and the changes are mostly explained by emotional stress. An exception to these studies is Gontokovsky et al [ 8 ] who reported a 26% decrease in serum glucose values after methylphenidate initiation.…”

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Methylphenidate has mild hyperglycemic and hypokalemia effects and increases leukocyte and neutrophil counts

et al. 2020

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Various psychotropic drugs may affect the hematological and biochemical profiles of plasma and its metabolism. Carbamazepine, the most well-known psychotropic drug, can cause substantial hyponatremia. Methylphenidate, a piperidine derivative structurally related to amphetamines, acts as a central nervous system stimulant. The current study evaluated whether methylphenidate affects hematological and biochemical parameters of patients diagnosed with attention deficit hyperactivity disorder. Patients undergoing treatment for attention deficit hyperactivity disorder at our Adolescent Psychiatric Clinic were enrolled in the study. Blood samples for complete blood count and common biochemical analyses were collected before patients started methylphenidate and after 3 months of continuous treatment. Participants included 64 patients comprised the study cohort. There were 48 (75%) males and 16 (25%) females, with a median age of 16 years (range 11–31). The total median potassium level decreased by 0.6 mg/dL ( P < .0001), while glucose rose by 15 mg/dL ( P < .0001), sodium decreased in 0.7meq/L, ( P = .006). The white blood count rose by 1350 cells/μL ( P < .033) due to neutrophilia, lymphocytosis and eosinophilia. Hemoglobin rose slightly by 0.1 ( P = .041). Changes in calcium, phosphorus, protein, albumin, and liver enzyme levels were not significant. The results indicate that methylphenidate may cause hypokalemia and elevated glucose, leukocyte, neutrophil, lymphocyte and eosinophil counts.

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Infant and Early Childhood Mental Health

Moser¹,

Todd²

2013

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Methylphenidate and Dyslipidemia

Cited by 3 publications

References 38 publications

Lipid Structural Effects of Oral Administration of Methylphenidate inDrosophilaBrain by Secondary Ion Mass Spectrometry Imaging

Lipid Structural Effects of Oral Administration of Methylphenidate inDrosophilaBrain by Secondary Ion Mass Spectrometry Imaging

Methylphenidate has mild hyperglycemic and hypokalemia effects and increases leukocyte and neutrophil counts

Infant and Early Childhood Mental Health

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