Methylphenidate and atomoxetine for treatment of nocturnal enuresis in a child with attention-deficit hyperactivity disorder

Bahalı, Kayhan; İpek, Hamiyet; Üneri, Özden Şükran

doi:10.1007/s00787-013-0414-x

Cited by 14 publications

(7 citation statements)

References 8 publications

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“…35 In addition, children with ADHD have been reported to be three times more likely to have persistent enuresis into adolescence or young adulthood. 13 Effective ADHD medications such as methylphenidate, 36 tricyclic antidepressants, and atomoxetine 37 have been reported to be effective for enuresis. In contrast, drugs used for the treatment of coexisting psychiatric disorders in patients with ADHD such as second-generation antipsychotic drugs may cause enuresis.…”

Section: Discussionmentioning

confidence: 99%

<p>Associations Between Psychiatric Disorders and Enuresis in Taiwanese Children: A National Population-Based Study</p>

Tsai

Chang

Chen

et al. 2020

CLEP

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Background: Psychiatric disorders such as attention-deficit/hyperactivity disorder may negatively impact drug compliance and the prognosis of enuresis. However, existing studies regarding associations between lifetime psychiatric disorders and childhood enuresis are primarily from Western countries, and studies from Taiwan are lacking. Methods: We conducted a population-based retrospective cohort analysis using the Taiwan Longitudinal Health Insurance Database 2010. A total of 1,146 children with enuresis (ICD-9-CM code: 307.6) and 4,584 randomly selected sex-and age-matched controls were identified between January 1, 1997 and December 31, 2011. Logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for the development of psychiatric disorders in the children with enuresis. Results: Enuresis was more common in the younger children, and the rate was significantly higher in boys (58.7%) than in girls (41.3%). A total of 171 patients (14.9%) in the enuresis group had at least one psychiatric diagnosis vs 259 (5.7%) in the control group (p<0.001). Multivariate analysis showed that the presence of enuresis increased the odds of developing major depressive/dysthymic disorder (OR=2.841, 95% CI: 1.619, 4.987), attention-deficit /hyperactivity disorder (OR=3.156, 95% CI: 2.446, 4.073), autism spectrum disorder (OR=2.468, 95% CI: 1.264, 4.822), anxiety disorders (OR=3.113, 95% CI: 2.063, 4.699), intelligence disability (OR=3.989, 95% CI: 2.476, 6.426), disruptive behavior disorders (OR=3.749, 95% CI: 1.756, 8.004), and tic disorder (OR=2.660, 95% CI: 1.642, 4.308). Conclusion: Children with enuresis are likely to have psychiatric disorders, and physicians should consider this during their evaluation.

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Section: Discussionmentioning

confidence: 99%

<p>Associations Between Psychiatric Disorders and Enuresis in Taiwanese Children: A National Population-Based Study</p>

Tsai

Chang

Chen

et al. 2020

CLEP

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“…Compared with other typical comorbid disorders such as conduct, depressive and anxiety disorders, the specific relevance of ADHD and incontinence is often neglected in research and in clinical practice . Although central nerve stimulants are the most effective pharmacological treatment option for ADHD, they do not have an anti‐enuretic effect and are thus not indicated in children with NE without ADHD, but there are two small case series of children with ADHD and comorbid NE showing a resolution of NE with stimulant treatment . Atomoxetine, a selective noradrenaline re‐uptake inhibitor, is effective in the treatment of ADHD.…”

Section: Discussionmentioning

confidence: 99%

Atomoxetine ameliorates nocturnal enuresis with subclinical attention‐deficit/hyperactivity disorder

Ohtomo

2016

Pediatrics International

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“…Finally, the treatment of ADHD was associated with reduction of wet nights in children with PMNE ( Ohtomo, 2017 ). This improvement was explained by several mechanisms including; the reduction of arousal threshold ( Bahali et al, 2013 ), the reduction of detrusor contractility and the increase in the bladder capacity ( Kovacevic et al, 2018 ) through the adrenergic and dopaminergic effects of the drugs used in treatment of ADHD ( Biederman and Spencer, 1999 , Bahali et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Impaired selective attention in patients with severe primary monosymptomatic nocturnal enuresis: An event-related potential study

Thabit

Elhamed

2021

Clinical Neurophysiology Practice

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Methylphenidate and atomoxetine for treatment of nocturnal enuresis in a child with attention-deficit hyperactivity disorder

Cited by 14 publications

References 8 publications

<p>Associations Between Psychiatric Disorders and Enuresis in Taiwanese Children: A National Population-Based Study</p>

<p>Associations Between Psychiatric Disorders and Enuresis in Taiwanese Children: A National Population-Based Study</p>

Atomoxetine ameliorates nocturnal enuresis with subclinical attention‐deficit/hyperactivity disorder

Impaired selective attention in patients with severe primary monosymptomatic nocturnal enuresis: An event-related potential study

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