Methylmercury-induced neurotoxicity and apoptosis

Ceccatelli, Sandra; Daré, Elisabetta; Moors, Michaela

doi:10.1016/j.cbi.2010.04.007

Cited by 274 publications

(188 citation statements)

References 121 publications

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“…Passive cell death via necrosis, on the other hand, is accompanied with swelling of cytoplasm and cell organelles followed by loss of membrane integrity and inflammation [43). The LDH release correlates with the plasma membrane integrity and is frequently applied as a marker of necrotic cell death.…”

Section: Ccf-sttglmentioning

confidence: 99%

“…However, none of the compounds resulted in a caspase-3 activation in the astrocytes. Several studies have provided evidence before that organic and inorganic Hg species can induce apoptosis in different cell types [10,[43][44][45][46][47] ..…”

Section: Ccf-sttglmentioning

confidence: 99%

“…Thus, the induction of apoptosis as cell death mechanism seems to be dependent on the respective species of origin and cell type. Intra-lysosomal oxidative processes as a result of oxidative stress may lead to lysosomal labilization and subsequently to apoptosis [43). Kaur et al reported increased levels of reactive oxygen species (ROS) following MeHgCl exposure in primary murine astrocytes and neurons with neurons as the more sensitive cell line [9).…”

Section: !I1oomentioning

confidence: 99%

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Toxicity of organic and inorganic mercury species in differentiated human neurons and human astrocytes

Lohren

Blagojevic

Fitkau

et al. 2015

Journal of Trace Elements in Medicine and Biology

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a b s t r a c tOrganic mercury (Hg) species exert their toxicity primarily in the central nervous system. The food relevant Hg species methylmercury (MeHg) has been frequently studied regarding its neurotoxic effects in vitro and in vivo. Neurotoxicity of thiomersal, which is used as a preservative in medical preparations, is to date less characterised. Due to dealkylation of organic Hg or oxidation of elemental Hg, inorganic Hg is present in the brain albeit these species are not able to readily cross the blood brain barrier. This study compared for the first time toxic effects of organic MeHg chloride (MeHgCl) and thiomersal as well as inorganic mercury chloride (HgCl 2 ) in differentiated human neurons (LUHMES) and human astrocytes (CCF-STTG1). The three Hg species differ in their degree and mechanism of toxicity in those two types of brain cells. Generally, neurons are more susceptible to Hg species induced cytotoxicity as compared to astrocytes. This might be due to the massive cellular mercury uptake in the differentiated neurons. The organic compounds exerted stronger cytotoxic effects as compared to inorganic HgCl 2 . In contrast to HgCl 2 exposure, organic Hg compounds seem to induce the apoptotic cascade in neurons following low-level exposure. No indicators for apoptosis were identified for both inorganic and organic mercury species in astrocytes. Our studies clearly demonstrate species-specific toxic mechanisms. A mixed exposure towards all Hg species in the brain can be assumed. Thus, prospectively coexposure studies as well as cocultures of neurons and astrocytes could provide additional information in the investigation of Hg induced neurotoxicity.

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Section: Ccf-sttglmentioning

confidence: 99%

Section: Ccf-sttglmentioning

confidence: 99%

Section: !I1oomentioning

confidence: 99%

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Toxicity of organic and inorganic mercury species in differentiated human neurons and human astrocytes

Lohren

Blagojevic

Fitkau

et al. 2015

Journal of Trace Elements in Medicine and Biology

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“…L'arsenic se présente également sous différentes formes; les formes inorganiques (As(III) et As(V)) qui sont considérées comme les plus toxiques, les formes méthylées peu toxiques, et les formes quaternaires considérées comme inoffensives (HUGUES, 2002 ;SAKURAI, 2002). Les composés organométalliques du mercure et de l'étain sont plus toxiques que les formes inorganiques en raison de leur grande liposolubilité qui leur permet de traverser les membranes biologiques et de bioaccumuler (CECCATELLI et al, 2010). Selon l'IUPAC (International Union of Pure and Applied Chemistry), la spéciation est définie comme étant la distribution d'un élément entre ses différentes espèces chimiques dans un échantillon donné (TEMPLETON et al, 2000).…”

Section: Introductionunclassified

Analyse de formes chimiques et de nanoparticules dans les échantillons d’eau : méthodes analytiques, préconcentration et validation

Séby

Dumont

Gleyzes

et al. 2015

rseau

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Il est maintenant reconnu que la mesure de la concentration totale d’un élément ne permet pas d’obtenir d’information fiable sur son impact environnemental et sa toxicité, ces éléments pouvant être présents sous différentes formes chimiques ou à l’état de nanoparticules (NPs). Il est alors nécessaire de faire appel à des techniques de fractionnement en taille pour les NPs ou à des analyses de spéciation permettant d'identifier et doser les différentes formes chimiques des éléments. Cette approche nécessite de disposer de protocoles d’échantillonnage, de conservation et de préparation d’échantillon stricts qui ne modifient pas la répartition des formes chimiques, notamment. Étant donné les nouvelles exigences des normes, cette approche nécessite également des outils analytiques de plus en plus précis, sensibles et robustes. Le couplage de techniques séparatives basées sur la chromatographie (liquide ou gazeuse) ou le fractionnement de flux, d’une part, et la spectrométrie de masse à plasma induit (ICP MS), d’autre part, présente un réel potentiel pour ces analyses. Ces approches sont détaillées d’une manière générale en termes de potentiels et de performances analytiques et des applications sont présentées pour différents éléments (As, Hg, Sn, Cr ou Sb). Au travers de ces différents exemples, sont particulièrement abordés :

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“…Contamination of the environment by heavy metals is a major concern because of their toxicity and threat to human life and the environment (1)(2)(3)(4). Cement factories have been reported as a major source of heavy metals emission into the environment with several reports showing higher concentrations of heavy metals in the vicinity of cement factories (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Contamination of barberry with heavy metals in the vicinity of Qayen Cement Company, Khorasan, Iran, in 2014: A Case study

Rezaei

Sayadi

Khaksarnejad

2014

JOHE

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Received: December 2015, Accepted: January 2016Background: Soil pollution and accumulation of heavy metals in crops in industrial areas is one of the most important environmental issues threatening the life of plants, animals, and humans. The aim of this study was to determine the concentration of Cr and Cd in the soil and barberry plants in farms surrounding the Qayen Cement Company, South Khorasan Province, Iran. Materials and Methods: In this study, 8 soil samples were collected from a depth of 0-30 cm and 30-60 cm and 4 samples of barberry plant containing fruits and leaves in summer 2014. The concentrations of Cr and Cd in the samples were determined using atomic absorption spectrometry. Results:The maximum concentration of Cr and Cd was observed in the soil sample collected from a depth of 0-30 cm (95.10 and 1.32 mg/kg of soil, respectively). The concentration of Cr and Cd was higher in the fruits of barberry than the leaves; 18.58 mg/kg and 59.45 µg/kg, respectively, which are higher than the standard values. Transfer factor was calculated as less than 1 for all stations. Conclusions: According to obtained results, Qayen Cement Company has the greatest impact on plants in this region. The barberry fruit is the strategic product in Qayen; therefore, attention to and management of the impact of the cement factory on agricultural products is necessary.

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Methylmercury-induced neurotoxicity and apoptosis

Cited by 274 publications

References 121 publications

Toxicity of organic and inorganic mercury species in differentiated human neurons and human astrocytes

Toxicity of organic and inorganic mercury species in differentiated human neurons and human astrocytes

Analyse de formes chimiques et de nanoparticules dans les échantillons d’eau : méthodes analytiques, préconcentration et validation

Contamination of barberry with heavy metals in the vicinity of Qayen Cement Company, Khorasan, Iran, in 2014: A Case study

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