Methylmercury exposure during prenatal and postnatal neurodevelopment promotes oxidative stress associated with motor and cognitive damages in rats: an environmental-experimental toxicology study

Fagundes, Beatriz Helena Fernandes; Nascimento, Priscila Cunha; Aragão, Walessa Alana Bragança; Chemelo, Victória Santos; Bittencourt, Leonardo Oliveira; Eiró-Quirino, Luciana; Silva, Márcia Cristina Freitas; Freire, Marco Aurélio M.; Fernandes, Luanna Melo Pereira; Maia, Cristiane do Socorro Ferraz; Crespo-López, María Elena; Lima, Rafael Rodrigues

doi:10.1016/j.toxrep.2022.02.014

Cited by 10 publications

(2 citation statements)

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“…Amazonian populations subside on fish, the main protein of the diet ( 50 ), and, therefore, their exposure to MeHg is a chronic problem. Recently, we have demonstrated that indirect exposure of the mother to MeHg causes damage to several brain regions, salivary glands and alveolar bone in the offspring ( 15 , 21 , 51 ).…”

Section: Discussionmentioning

confidence: 99%

Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels: a concern for oral health

Chemelo

Bittencourt

Nascimento

et al. 2023

Front. Public Health

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Although there are many studies on the health effects of methylmercury (MeHg) toxicity during in utero and early development, little is known about its effects on mineralized tissues present in the oral cavity, such as enamel structure. Therefore, this study evaluated the effects of MeHg exposure on the physico-chemical, ultrastructural and functional properties of mature tooth enamel. Specifically, we studied offspring of mothers exposed to MeHg during the prenatal and postnatal periods which are the developmental stages associated with tooth enamel formation. Female rats were exposed to MeHg at a dose of 40 μg/kg/day for 42 days of pregnancy and lactation. The enamel of offspring was analyzed by (1) Fourier Transform Infrared Spectroscopy and Raman to assess physicochemical composition, (2) Scanning Electron Microscopy for ultrastructural evaluation, (3) Transmitted Polarizing Light Microscopy for analysis of the enamel extracellular matrix, and (4) resistance and hardness were evaluated by microhardness. The results showed that MeHg exposure during this sensitive enamel formation period induced changes in inorganic and organic content and enamel prisms ultrastructure alterations and disturbed the organic extracellular matrix due to a decreased enamel strength. These novel findings establish for the first time that maternal exposure to MeHg pre and postnatal promoted relevant changes in mature enamel of their offspring rats.

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Section: Discussionmentioning

confidence: 99%

Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels: a concern for oral health

Chemelo

Bittencourt

Nascimento

et al. 2023

Front. Public Health

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“…7 Hg 2+ can be stable in aqueous solution and is extremely toxic to specific enzymes and proteins in living organisms. 8–10 Compared to Hg 2+ , CH 3 Hg + is lipid-soluble and crosses biological membranes easily, causing damage to the kidneys, especially to the renal tubular epithelial cells in the proximal part of the kidneys, 11,12 when it enters the body of humans and animals through fish and shrimps. 13 In addition, mercury can cause immune dysfunction 14 and damage cerebral nerves 15,16 and endocrine systems.…”

Section: Introductionmentioning

confidence: 99%

A triphenylamine-based fluorescent probe with phenylboronic acid for highly selective detection of Hg²⁺ and CH₃Hg⁺ in groundwater

et al. 2023

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Behavioral neuroscience in zebrafish: unravelling the complexity of brain-behavior relationships

Firdous,

Pal,

Khanam

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Methylmercury exposure during prenatal and postnatal neurodevelopment promotes oxidative stress associated with motor and cognitive damages in rats: an environmental-experimental toxicology study

Cited by 10 publications

References 114 publications

Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels: a concern for oral health

Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels: a concern for oral health

A triphenylamine-based fluorescent probe with phenylboronic acid for highly selective detection of Hg²⁺ and CH₃Hg⁺ in groundwater

Behavioral neuroscience in zebrafish: unravelling the complexity of brain-behavior relationships

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Methylmercury exposure during prenatal and postnatal neurodevelopment promotes oxidative stress associated with motor and cognitive damages in rats: an environmental-experimental toxicology study

Cited by 10 publications

References 114 publications

Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels: a concern for oral health

Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels: a concern for oral health

A triphenylamine-based fluorescent probe with phenylboronic acid for highly selective detection of Hg2+ and CH3Hg+ in groundwater

Behavioral neuroscience in zebrafish: unravelling the complexity of brain-behavior relationships

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Product

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A triphenylamine-based fluorescent probe with phenylboronic acid for highly selective detection of Hg²⁺ and CH₃Hg⁺ in groundwater