Methylmercury Causes Neurodegeneration and Downregulation of Myelin Basic Protein in the Spinal Cord of Offspring Rats after Maternal Exposure

Silva, Diane Cleydes Baia da; Bittencourt, Leonardo Oliveira; Baia-da-Silva, Daiane Claydes; Chemelo, Victória Santos; Eiró-Quirino, Luciana; Nascimento, Priscila Cunha; Silva, Márcia Cristina Freitas; Freire, Marco Aurélio M.; Gomes-Leal, Walace; Crespo-López, María Elena; Lima, Rafael Rodrigues

doi:10.3390/ijms23073777

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…Among the selected articles, the effects of alcohol on the prefrontal cortex ( Moselhy et al, 2001 ; Medina et al, 2008 ; Crews and Boettiger, 2009 ), hippocampus ( Berman and Hannigan, 2000 ; De Bellis et al, 2000 ; Nixon and Crews, 2002 ; Livy et al, 2003 ), cerebellum ( da Silva et al, 2018 ; Lamarão-Vieira et al, 2019 ), thalamic nucleus ( Harding et al, 2000 ), amygdala ( Pich et al, 1995 ; Roberto et al, 2003 ), and corpus callosum ( Riley et al, 1995 ; Bookstein et al, 2002 ). However, the mechanisms of alcohol neurotoxicity are still not completely understood, requiring studies that evaluate other regions of the nervous system, such as the spinal cord, where initial studies show sensitivity to alcohol ( da Silva et al, 2018 ) as well as to other toxic substances ( da Silva et al, 2022 ; Eiró-Quirino et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Neurotoxicology of alcohol: a bibliometric and science mapping analysis

Mendes,

Baia-da-Silva,

Melo

et al. 2023

Front. Pharmacol.

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Alcohol consumption is common in many societies and has increased considerably, resulting in many socioeconomic and public health problems. In this sense, studies have been carried out in order to understand the mechanisms involved in alcohol consumption and related harmful effects. This study aimed to identify and map the knowledge and to perform bibliometric analysis of the neurotoxicology of alcohol based on the 100 most cited articles. A search was carried out in the Web of Science Core Collection database and information was extracted regarding the journal, authors, keywords, year of publication, number of citations, country and continent of the corresponding author. For each selected manuscript, the study design, alcohol exposure model, dose, period of exposure, and effect on the central nervous system and research hotspots were mapped. The journal with the highest number of publications was Alcoholism: Clinical and Experimental Research (n = 11 papers), the author who contributed the most was Crews FT (n = 8 papers), the studies had a total of 288 keywords and 75% of the publications were from the United States of America. The experimental studies evaluated the effects of prenatal and postnatal exposure and were conducted in rats and mice using doses ranging from 2.5 to 14 g/kg/day, with administration by subcutaneous, intraperitoneal, intragastric, or inhalation route or with free access through drinking bottles. Among the studies mapped, the oldest one (1989) aimed to understand the systemic damage and mechanisms of action involved, while the most recent focused on understanding the receptors and mechanisms involved in addiction, as well as genetic factors. Our results show the panorama of the most widespread scientific production in the scientific community on the neurotoxicology of ethanol, a high prevalence was observed in studies that addressed fetal alcohol syndrome and/or the effects of ethanol on neurodevelopment.

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Section: Discussionmentioning

confidence: 99%

Neurotoxicology of alcohol: a bibliometric and science mapping analysis

Mendes,

Baia-da-Silva,

Melo

et al. 2023

Front. Pharmacol.

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“…Cadmium toxicity was tied to excessive production of ROS, leading to oligodendrocyte death or dysfunction. In addition, MeHg toxicity is linked to the downregulation of MBP in pregnant and lactating rats [134]. MBP is essential for the construction and function of the myelin sheaths by oligodendrocytes and Schwann cells.…”

Section: Axonal Demyelinationmentioning

confidence: 99%

Metal Profiles in Autism Spectrum Disorders: A Crosstalk between Toxic and Essential Metals

Błażewicz

Grabrucker

2022

IJMS

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Since hundreds of years ago, metals have been recognized as impacting our body’s physiology. As a result, they have been studied as a potential cure for many ailments as well as a cause of acute or chronic poisoning. However, the link between aberrant metal levels and neuropsychiatric illnesses such as schizophrenia and neurodevelopmental disorders, such as autism spectrum disorders (ASDs), is a relatively new finding, despite some evident ASD-related consequences of shortage or excess of specific metals. In this review, we will summarize past and current results explaining the pathomechanisms of toxic metals at the cellular and molecular levels that are still not fully understood. While toxic metals may interfere with dozens of physiological processes concurrently, we will focus on ASD-relevant activity such as inflammation/immune activation, mitochondrial malfunction, increased oxidative stress, impairment of axonal myelination, and synapse formation and function. In particular, we will highlight the competition with essential metals that may explain why both the presence of certain toxic metals and the absence of certain essential metals have emerged as risk factors for ASD. Although often investigated separately, through the agonistic and antagonistic effects of metals, a common metal imbalance may result in relation to ASD.

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