Methyllycaconitine (MLA) blocks the nicotine evoked anxiogenic effect and 5-HT release in the dorsal hippocampus: possible role of α7 receptors

Tucci, Sonia; Genn, Rachel F.; File, Sandra E.

doi:10.1016/s0028-3908(02)00391-x

Cited by 59 publications

(41 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Knockout mice lacking the β3 or β4 subunits showed decreased levels of anxiety-like behaviour (Booker et al 2007;Cui et al 2003;Salas et al 2003), as did α7 knockout mice (Paylor et al 1998). The selective antagonist MLA had an anxiolytic effect in the social interaction test (Tucci et al 2003), further supporting the involvement of the α7 subtype in the modulation of anxiety.…”

Section: Studies In Animalsmentioning

confidence: 55%

“…It has been suggested that these effects are dose-dependent: low doses of nicotine are believed to have anxiolytic effects, whereas higher doses act anxiogenic (e.g. Brioni et al 1993;Cao et al 1993;File et al 1998b;Ouagazzal et al 1999;Tucci et al 2003). Moreover, the effects of nicotine appear to depend on the paradigm tested and the affected neurobiological substrates.…”

Section: Studies In Animalsmentioning

confidence: 99%

See 1 more Smart Citation

Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: An overview of preclinical and clinical findings

et al. 2011

View full text Add to dashboard Cite

show abstract

Section: Studies In Animalsmentioning

confidence: 55%

Section: Studies In Animalsmentioning

confidence: 99%

Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: An overview of preclinical and clinical findings

et al. 2011

View full text Add to dashboard Cite

show abstract

“…It is possible that ␣7nAChRs expressed by serotonin neurons in the monkey DR play an important role in the regulation of serotonin release controlled by ACh. There is evidence that serotonin released from the DR is controlled by ACh acting on the ␣7nAChR (Li et al, 1998;Tucci et al, 2003). In earlier studies, an interaction between brainstem ACh and serotonin neurons was implicated in the control of sleep cycles (Steriade and McCarley, 1990).…”

Section: Discussionmentioning

confidence: 99%

Estradiol increases α7 nicotinic receptor in serotonergic dorsal raphe and noradrenergic locus coeruleus neurons of macaques

Centeno

Henderson

Pau

et al. 2006

J of Comparative Neurology

View full text Add to dashboard Cite

Acetylcholine, acting on presynaptic nicotinic receptors (nAChRs), modulates the release of neurotransmitters in the brain. The rat dorsal raphe nucleus (DR) and the locus coeruleus (LC) receive cholinergic input and express the alpha7nAChR. In previous reports, we demonstrated that estradiol (E) administration stimulates DR serotonergic and LC noradrenergic function in the macaque. In addition, it has been reported that E induces the expression of the alpha7nAChR in rats. We questioned whether E increased the expression of the alpha7nAChR in the macaque DR and LC. We utilized double immunostaining to study the effect of a simulated preovulatory surge of E on the expression of the alpha7nAChR in the DR and the LC and to determine whether alpha7nAChR colocalizes with serotonin and tyrosine hydroxylase (TH) in macaques. There was no difference in the number of alpha7nAChR-positive neurons between ovariectomized (OVX) controls and OVX animals treated with a silastic capsule containing E (Ecap). However, supplemental infusion of E for 5-30 hours to Ecap animals (Ecap + inf) significantly increased the number of alpha7nAChR-positive neurons in DR and LC. In addition, supplemental E infusion significantly increased the number of neurons in which alpha7nAChR colocalized with serotonin and TH. These results constitute an important antecedent for study of the effects of nicotine and ovarian steroid hormones in the physiological functions regulated by the DR and the LC in women.

show abstract

“…Pharmacological experiments have implicated these receptors in several effects of nicotine such as aversion and reward (Laviolette and van der Kooy, 2003), anxiety-like behavior (Tucci et al, 2003) and working memory (Levin, 2002). The generation of mice carrying an α7 null mutation provided a new tool for investigating the role of this subunit in the CNS (Orr-Urtreger et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Decreased withdrawal symptoms but normal tolerance to nicotine in mice null for the α7 nicotinic acetylcholine receptor subunit

et al. 2007

View full text Add to dashboard Cite

Withdrawal symptoms are a major deterrent when people try to quit smoking. The α7 subunit of the neuronal nicotinic acetylcholine receptor (nAChR) is highly expressed in the brain, and has been suspected to play a major role in nicotine addiction. We studied the influence of α7-containing nAChRs on nicotine withdrawal and tolerance, in wild type mice and mice null for the α 7 nAChR subunit (α7 −/−). For withdrawal experiments, animals were implanted with osmotic minipumps delivering nicotine for 13 days. A single intraperitoneal injection of the nAChR antagonists mecamylamine (MEC) or methyllycaconitine (MLA) was used to precipitate withdrawal. In wild type mice, both MEC and MLA precipitated somatic signs of withdrawal such as increased grooming, scratching and shaking. In α7 −/− mice, the somatic effects of MEC-precipitated nicotine withdrawal were significantly reduced. Interestingly, the presumed α7-specific antagonist MLA also precipitated withdrawal. Tolerance, which was measured as a decrease in nicotine-induced hypolocomotion after subchronic nicotine treatment, was normal in α7 −/− mice. Finally, because anxiety and withdrawal symptoms are highly correlated in humans, we studied anxiety-like behaviors in α7 −/− mice using a battery of anxiety-related tests. The behavior of α7 −/− mice was indistinguishable from that of control mice. Our results point to the α7 subunit as one of the players in nicotine withdrawal, but not in nicotine tolerance or basal anxiety-like behavior.

show abstract

Methyllycaconitine (MLA) blocks the nicotine evoked anxiogenic effect and 5-HT release in the dorsal hippocampus: possible role of α7 receptors

Cited by 59 publications

References 30 publications

Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: An overview of preclinical and clinical findings

Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: An overview of preclinical and clinical findings

Estradiol increases α7 nicotinic receptor in serotonergic dorsal raphe and noradrenergic locus coeruleus neurons of macaques

Decreased withdrawal symptoms but normal tolerance to nicotine in mice null for the α7 nicotinic acetylcholine receptor subunit

Contact Info

Product

Resources

About